Molecular pathogenesis of cholestasis /

Bibliographic Details
Other Authors:	Trauner, Michael, Jansen, Peter L. M.
Format:	Book
Language:	English
Published:	Georgetown, Tex. : New York : Landes Bioscience/Eurekah.com ; Kluwer Academic/Plenum Publishers, [2004]
Subjects:	Cholestasis > genetics. Cholestasis > metabolism. Cholestasis > physiopathology. Molecular Biology > methods.

Table of Contents:

Mechanisms of bile formation : an introduction
Hepatocellular transport systems : basolater membrane
The ABC of canalicular transport
Gap junctions in the liver
Cholestasis : an intracellular "traffic jam"
The pathobiology of cholangiocytes
Genetics, mutations, and polymorphisms
Transcriptional regulation of hepatobiliary transporters
Signal transduction in bile formation and cholestasis
Bile acid-medicated apoptosis in cholestasis
Hepatic drug metabolism
Pathology of cholestasis
Disorders of bile acid transport
Genetic defects in biliary lipid transport
Transport of bilirubin conjugates across hepatocellular membrane domains and the conjugated hyperbilirubinemia
Hepatic copper transport
Molecular basis of primary biliary cirrhosis
Primary sclerosing cholangitis
Drug-induced cholestatic liver disease
Acquired alterations of transporter expression
Pathophysiological basis of pruritus and fatigue in cholestasis
Bone disease in chronic cholestatic liver disease
Fat absorption and lipid metabolism in cholestasis
Medical therapy of cholestatic liver diseases
Hepatocyte transplantation and liver-directed gene therapy