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HMG-CoA reductase inhibitors /

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Bibliographic Details
Other Authors: Schmitz, G. (Gerd), 1949-, Torzewski, M. (Michael)
Format: Book
Language:English
Published: Basel ; Boston : Birkhäuser Verlag, [2002]
Series:Milestones in drug therapy.
Subjects:
Hydroxymethylglutaryl-CoA Synthase > physiology.
Anticholesteremic Agents > antagonists & inhibitors.
Hypercholesterolemia > prevention & control.
Table of Contents:
  • History and development of HMG-CoA reductase inhibitors
  • Structure and mechanisms of action of HMG-CoA reductase inhibitors
  • Sterol-regulatory element binding proteins (SREBPs) : gene-regulatory target of statin action
  • Cellular effects of HMG-CoA reductase inhibitors on blood cells (monocytes, macrophages, platelets)
  • Pleiotropic effects of HMG-CoA reductase inhibitors on cells of the vascular wall
  • Indications and contro-indications for statin treatment (primary and secondary prevention of hypercholestrolemia)
  • Clinical experience : studies with HMG-CoA reductase inhibitors
  • Cost-effectiveness of statins in primary and secondary prevention of coronary heart disease