Stereochemical aspects of drug action and disposition /
| Other Authors: | , , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Berlin : New York :
Springer,
[2003]
|
| Series: | Handbook of experimental pharmacology.
v. 153. |
| Subjects: |
Table of Contents:
- sect. I : Chemical aspects
- ch. 1. Recent developments in asymmetric organic synthesis : principles and examples
- ch. 2. Stereoselective seperations : recent advances in capillary electrophoresis and high-performance liquid chromatography
- ch. 3. Sterochemical issues in bioactive natural products
- ch. 4. Drug racemization and its significance in pharmaceutical research
- ch. 5. Physical properties and crystal structures of chiral drugs
- sect. II : Experimental pharmacology
- ch. 6. Chiral recognition in biochemical pharmacology : an overview
- ch. 7. Enantioselectivity in drug-receptor interactions
- ch. 8. Mechanisms of stereoselective binding to functional proteins
- ch. 9. Stereoselective drug-channel interactions
- ch. 10. Stereoselective bioactivation and bioinactivation - toxicological aspects
- sect. III : Drug absorption, distribution, metabolism, elimination
- ch. 11. Intestinal drug transport : stereochemical aspects
- ch. 12. Enantioselective plasma and tissue binding
- ch. 13. Stereoselective drug metabolism and drug interactions
- ch. 14. Metabolic chiral inversion of 2-arylpropionic acids
- ch. 15. Stereoselective renal eliminations
- sect. IV : Implications for drug development and therapy
- ch. 16. Regulatory requirements for the development of chirally active drugs
- ch. 17. Improving clinical risk/benefit through stereochemistry