Recombinant antibodies for cancer therapy : methods and protocols /
| Other Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Totowa, N.J. :
Humana Press,
[2003]
|
| Series: | Methods in molecular biology (Clifton, N.J.) ;
v. 207. |
| Subjects: |
Table of Contents:
- Generation of antibody molecules through antibody engineering
- Application of recombinant antibodies in cancer patients
- DNA immunization as a means to generate antibodies to proteins
- Chimerization if a monoclonal antibody for treating hodgkin's lymphoma
- Humanization of monoclonal antibodies by CDR grafting
- Generation and screening of a modular human scFv expression library from multiple donors
- Construction of semisynthetic antibody libraries
- Single-domain VH antibody fragments from a phage display library
- Isolation of human fab fragments against ovarian carcinoma using guided selection
- Human recombinant fab antibodies with T-cell receptor-like specifications generated from phage display libraries
- Engineering hot spots for affinity enhancement of antibodies
- Simultaneous humanization and affinity optimization of monoclonol antibodies
- Tailoring kinetics of antibodies using focused combinatorial libraries
- Engineering scFvs for improved stability
- Recombinant single-chain and disulfide-stabilized Fv immunotoxins for cancer therapy
- Generation of recombinant immunotoxins for specific targeting of tumor-related peptides presented by MHC molecules
- Construction and characterization of RNase-based targeted therapeutics
- Bispecific diabodies for cancer therapy
- Generation and characterization of bispecific tandem diabodies for tumor therapy
- Generation of recombinant multimeric antibody fragments for tumor diagnosis and therapy
- Construction and characterization of minibodies for imaging and therapy of colorectal carcinomas
- Generation, expression, and monitoring of recombinant immune receptors for use in cellular immunotherapy
- Tailoring natural effector functions : antibody engineering beyond humanization
- Single-chain Fv-based affinity purification of the cellular stress protein gp96 for vaccine development
- Recombinant adenoviruses for in vivo expression of antibody fragments
- Production of antibody fragments in a bioreactor
- Large scale production of recombinant antibodies by utilizing cellulose-binding domains
- Production of tumor-specific antibodies in tobacco