Peptide research protocols : endothelin /

Bibliographic Details
Other Authors: Maguire, Janet J., Davenport, Anthony P.
Format: Book
Language:English
Published: Totowa, N.J. : Humana Press, [2002]
Series:Methods in molecular biology (Clifton, N.J.) ; v. 206.
Subjects:
Table of Contents:
  • Immunocytochemical localization of endothelin peptides, precursors, and endothelin-converting enzymes
  • Analysis of endothelins by enzyme-linked immunosorbent assay and radioimmunoassay
  • Seperation of endothelin isoforms by high performance liquid chromatography and detection by radioimmunoassay
  • Radioligand binding assays and quantitative autoradiography of endothelin receptors
  • Using receptor antagonists in binding studies to characterize a mammalian endothelin receptor
  • Quantification of endothelin receptor mRNA by competitive RT-PCR
  • Detection and assessment of endothelin-converting enzyme activity
  • Quantitative measurement of mRNA levels by RT-PCR: studies of ECE-1 isoforms
  • Evaluation of endothelin-converting enzyme inhibitors using cultured cells
  • Endothelin-converting enzyme activity in vascular smooth muscle preparations in vitro
  • Characterization of a new endothelin receptor ligand by in vitro assays
  • Use of in vitro organ cultures of human saphenous vein as a model for intimal proliferation
  • Investigation of the endothelin system in experimental heart failure
  • Local forearm vasoconstriction to endothelin-1 measured by venous occlusion plethysmography in vivo.