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The genetic basis of human cancer /

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Bibliographic Details
Other Authors: Vogelstein, Bert, Kinzler, Kenneth W.
Format: Book
Language:English
Published: New York : McGraw-Hill, Medical Pub. Division, [2002]
Edition:Second edition.
Subjects:
Neoplasms > genetics.
Cell Transformation, Neoplastic > genetics.
Gene Expression > genetics.
Mutagenesis > genetics.
Table of Contents:
  • Pt. 1. Basic concepts in cancer genetics
  • Introduction
  • The nature and mechanisms of human gene mutation
  • Genomic imprinting and cancer
  • Genes altered by chromosomal translocations in leukemia and lymphomas
  • Chromosome alterations in human solid tumors
  • Gene amplification in human cancers: biological and clinical significance
  • Tumor genome instability
  • Gene expression profiling in cancer
  • Pt. 2. Controls on cell cycle
  • Cell cycle control: an overview
  • Apoptosis and cancer
  • Oncogenes
  • Tumor-suppressor genes
  • Pt. 3. Familial cancer syndromes
  • Sect. 1. Overview
  • Familial cancer syndromes: role of caretakers and gatekeepers
  • Sect. 2. Defects in caretakers
  • Nucleotide excision repair syndromes: xeroderma pigmentosum, cockayne syndrome, and trichothiodystrophy
  • Ataxia-telangiectasia
  • Bloom syndrome
  • Fanconi anemia
  • Hereditary nonpolyposis colorectal cancer (HNPCC)
  • Werner syndrome
  • Peutz-Jeghers syndrome
  • Juvenile polyposis syndrome
  • Sect. 3. Defects in gatekeepers
  • Retinoblastoma
  • Li-Fraumeni syndrome
  • Wilms tumor
  • Neurofibromatosis 1
  • Neurofibromatosis 2
  • Renal carcinoma
  • Multiple endocrine neoplasia type 1
  • Multiple endocrine neoplasia type 2
  • Malignant melanoma
  • Cowden syndrome
  • Skin cancer (including nevoid basal cell carcinoma syndrome)
  • Breast cancer
  • Colorectal tumors
  • Pilomatricoma and pilomatrix carcinoma
  • Hereditary paragangliomas of the head and neck
  • Cylindromatosis
  • Familial cardiac myxomas and carney complex
  • Sect. 4. Managing familial cancer syndromes
  • Genetic testing for familial cancer
  • Pt. 4. Cancer by site
  • Pancreatic cancer
  • Ovarian cancer
  • Endometrial cancer
  • Cervical cancer
  • Bladder cancer
  • Stomach cancer
  • Prostate cancer
  • Brain tumors
  • Lung cancer
  • Hepatocellular carcinoma
  • Clinical and biological aspects of neuroblastoma
  • Cancers of the oral cavity and pharynx
  • Genetic abnormalities in lymphoid malignancies.