Insulin signaling : from cultured cells to animal models /

Bibliographic Details
Other Authors:	Grunberger, George, Zick, Yehiel
Format:	Book
Language:	English
Published:	London ; New York : Taylor & Francis, 2002.
Series:	Frontiers in animal diabetes research ; v. 3.
Subjects:	Insulin > physiology. Receptor, Insulin > physiology. Diabetes Mellitus, Experimental. Models, Animal. Mice, Transgenic. Mice, Knockout. Disease Models, Animal.

Table of Contents:

I. Structural aspects of the insulin receptor and its downstream effectors
Mutations in the insulin receptor gene
Insulin receptor folding
IRS protein structure
II. Insulin signaling cascades
The molecular basis of insulin action
Grb-10 in peptide hormone action
Regulation of protein kinase B : implications for insulin signaling
Insulin mediated S6 kinase activation : role in translation, cell growth and insulin production
Role of serine/threonine protein kinase, Raf-1, in insulin mediated metabolic signaling
PKC as downstream effector of PI3 kinase in rat adipocytes
III. Molecular aspects of insulin action
PIKfyve and acute insulin actions
Insulin action in vascular endothelium
GLUT4 traffic report : molecular mechanisms of insulin-stimulated GLUT4 trafficking in adipocytes
Insulin receptor trafficking
Ser/Thr phosphorylation of insulin receptor signaling molecules and insulin resistance
Tryosine kinase inhibitors
Abnormal p85/p110 type PI-kinase activation in Zucker furry rats and high-fat fed rats
The role of PKC for insulin receptor signaling
Pharmacological approaches to insulin resistance in the Zucker diabetic furry rat
IV. Transgenics and gene knockout models of insulin action
Lessons from targeted gene knockouts of the insulin receptor
Animal models of IRS-1/IRS-2 knockouts
Metabolic perturbations in mice engineered to have altered GLUT4
Glucose transporters and cardiac function : insights from heart selective GLUT4 knockout mice
Insights from mouse models deficient in protein-tryosine phosphatases that regulate the insulin action pathway