Fluoropyrimidines in cancer therapy /

Bibliographic Details
Other Authors: Rustum, Youcef M.
Format: Book
Language:English
Published: Totowa, N.J. : Humana Press, [2003]
Series:Cancer drug discovery and development.
Subjects:
Table of Contents:
  • Relative role of 5-fluorouracil activation and inactivation pathways on its cytotoxic effects : preclinical and clinical modulation
  • Dihydropyrimidines : past and future directions
  • Biochemical bases of the 5-fluorouracil-folinic acid interaction and of its limitations : a retrospective analysis
  • Molecular mechanisms regulating the expression of thymidylate synthase
  • Regulation of thymidylate synthase gene expression and drug response : posttranscriptional regulation and cell population density
  • Death receptor signaling in the mechanism of 5-fluorouracil action
  • Circadian rhythms in 5-fluorouracil pharmacology and therapeutic applications
  • Relevance of scheduling to the efficacy of 5-fluorouracil alone and in combination with other agents
  • Noninvasive studies of fluoropyrimidines
  • Comparative antitumor activity of 5-fluorouracil (5-FU) prodrugs in preclinical model systems : role of leucovorin and dihydropyrimidine dehydrogenase inhibitors
  • Bimonthly 48-h leucovorin and 5-fluorouracil-based regimens in advanced colorectal cancer
  • Review on the combination of systemic and locoregional treatment for colorectal liver metastases
  • Fluoropyrimidines in advanced colorectal cancer : a review of six consecutive meta-analyses
  • The Mayo/NCCTG experience with 5-fluorouracil and leucovorin in adjuvant advanced colorectal cancer
  • Fluoropyrimidines for the adjuvant treatment of colorectal cancer : the NSABP experience
  • Clinical trials of UFT leucovorin in gastrointestinal malignancies
  • The development of oral UFT with and without leucovorin
  • UFT in elderly patients with colorectal cancer
  • Clinical trials of the eniluracil/5-fluorouracil combination
  • Discovery and preclinical pharmacology of capecitabine
  • Capecitabine, a tumor-targeting oral fluoropyrimidine : molecular rationale and clinical validation
  • Capecitabine : a rationally developed anticancer drug
  • Preclinical and clinical practice of S-1 in Japan
  • Preclinical and clinical practice of low-dose FP therapy in Japan : Japanese use of low-dose FP therapy