Protein sequencing protocols /

Bibliographic Details
Other Authors: Smith, Bryan John
Format: Book
Language:English
Published: Totowa, N.J. : Humana Press, [2003]
Edition:Second edition.
Series:Methods in molecular biology ; v. 211.
Subjects:
Table of Contents:
  • Strategies for handling polypeptides on a micro-scale
  • SDS polyacrylamide gel electrophoresis for N-terminal protein sequencing
  • Two-dimensional polyacrylamide gel electrophoresis for the separation of proteins for chemical characterization
  • Electroblotting of proteins from polyacrylamide gels for chemical characterization
  • Enzymatic cleavage of proteins
  • Chemical cleavage of polypeptides
  • Enzymatic preparation and isolation of glycopeptides
  • Analytical and micropreparative capillary electrophoresis of peptides
  • High-performance liquid chromatography on-line derivative spectroscopy for the characterization of peptides with aromatic amino acid residues
  • Hydrolysis of samples for amino acid analysis
  • Amino acid analysis : precolumn derivatization methods
  • Post column amino acid analysis
  • Amino acid analysis using pre-column derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate : analysis of hydrolyzed proteins and electroblotted samples
  • Amino acid analysis in protein hydrolysates using anion exchange chromatography and IPAD detection
  • D-amino acid analysis
  • Validation of amino acid analysis methods
  • Electrospray mass spectrometry of peptides, proteins and glycoproteins
  • Peptide mass fingerprinting using MALDI-TOF mass spectrometry
  • Nanoelectrospray tandem mass spectrometry and sequence similarity searching for identification of proteins from organisms with unknown genomes
  • Direct identification of proteins in ultracomplex mixtures : applications to proteome analysis
  • Identification of PTH-amino acids by HPLC
  • Protein sequencer maintenance and troubleshooting
  • N-Terminal protein sequencing for special applications
  • Identification of phosphorylation sites by edman degradation
  • Validation of protein sequencing in a regulated laboratory
  • Automated C-terminal protein sequence analysis using the alkylated-thiohydantoin method
  • Chemical modifications of proteins as an aid to sequence analysis
  • Deblocking of N-terminally modified proteins
  • Deblocking of proteins containing N-terminal pyroglutamic Acid
  • Identification of sites of glycosylation
  • Analysis of sites of protein phosphorylation
  • Quantitation and location of disulfide bonds in proteins
  • Getting the most from your protein sequence
  • Appendix 1 : Letter codes, structures, masses, and derivatives of amino acids
  • Appendix 2 : Protein consensus sequence motifs