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Bibliographic Details
Main Author: Ptashne, Mark
Other Authors: Gann, Alexander, 1954-
Format: Book
Language:English
Published: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, [2002]
Subjects:
Gene Expression Regulation, Bacterial.
Table of Contents:
  • Lessons from bacteria
  • RNA polymerase
  • Regulated recruitment: the lac genes
  • More regulated recruitment: the bacteriophage
  • Polymerase activation: glnA and related genes
  • Promoter activation: merT and related genes
  • Yeast : a single-celled eukaryote
  • RNA polymerase
  • Other parts of the transcriptional machinery
  • An overview of activation
  • A model case: the GAL genes
  • How Gal4 works
  • Signal integration and combinatorial control
  • Silencing
  • Some notes on higher eukaryotes
  • Mechanism of activation: recruitment
  • What is recruited?
  • Repression
  • Detecting and transmitting physiological signals
  • Signal integration, combinatorial control, and alternative enhancers
  • Action at a distance
  • DNA methylation, insulators, and imprinting
  • Chromosomal position and gene expression
  • Compartmentalization
  • Enzyme specificity and regulation
  • Ubiquitylation and proteolysis
  • Splicing
  • Imposing specificity on kinases
  • Interim summary and extensions
  • Further generalizations.