http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
2 volumes, 48 unnumbered pages of color plates : illustrations (some color) ; 29 cm.
Vol. 1. -- Pt. I. Basic principles -- A. Cell biology -- Structure and development of the skeleton -- Biomechanics of bone -- Embryonic development of bone and the molecular regulation of intramembranous and endochondral bone formation -- Mesenchymal stem cells and osteoblast differentiation -- Transcriptional control of osteoblast differentiation and function -- The osteocyte -- Cells of bone: osteoclast generation -- Osteoclast function: biology and mechanisms -- Integrin and calcitonin receptor signaling in the regulation of the cytoskeleton and function of osteoclasts -- Apoptosis in bone cells -- Involvement of nuclear architecture in regulating gene expression in bone cells -- B. Biochemistry -- Type I collagen: structure, synthesis, and regulation -- Collagen cross-linking and metabolism -- Bone matrix proteoglycans and glycoproteins -- Osteopontin -- Bone proteinases -- Integrins and other cell surface attachment molecules of bone cells -- Intercellular junctions and cell-cell communication in bone -- C. Bone remodeling and mineral homeostasis -- Histomorphometric analysis of bone remodeling -- Phosphorus homeostasis and related disorders -- Magnesium homeostasis -- Meals in bone: aluminum, boron, cadmium, chromium, lead, silicon, and strontium -- Biology of the extracellular CA²⁺-sensing receptor (CaR) -- D. The hormones of bone -- Receptors for parathyroid hormone (PTH) and PTH-related peptide -- Parathyroid hormone: molecular biology -- Parathyroid hormone-receptor interactions -- Actions of parathyroid hormone -- Renal and skeletal actions of parathyroid hormone (PTH) and PTH-related protein -- Physiological actions of parathyroid hormone (PTH) and PTH-related protein: epidermal, mammary, reproductive, and pancreatic tissues -- Vascular, cardiovascular, and neurological actions of parathyroid-related protein -- 1α,25(OH)₂ Vitamin D₃: nuclear receptor structure (VDR) and ligand specificities for genomic and rapid biological responses -- Vitamin D gene regulation -- Photobiology and noncalcemic actions of Vitamin D -- Structure and molecular biology of the calcitonin receptor -- Calcitonin gene family of peptides: structure, molecular biology, and effects -- Amylin and calcitonin gene-related peptide -- E. Other systemic hormones that influence bone metabolism -- Estrogens and progestins -- Selective estrogen receptor modulators -- Mechanisms of estrogen action in bone -- Thyroid hormone and bone -- Clinical and basic aspects of glucocorticoid action in bone -- Effects of diabetes and insulin on bone physiology -- Androgens: receptor expression and steroid action in bone -- Kinins and neuro-osteogenic factors -- F. Local regulators -- The role of insulin-like growth factors and binding proteins in bone cell biology -- Platelet-derived growth factor and the skeleton -- Fibroblast growth factor (FGF) and FGF receptor families in bone -- Vol. 2. -- Vascular endothelial growth factors -- Transforming growth factor-β -- Bone morphogenetic proteins -- Bone morphogenetic protein receptors and actions -- Colony-stimulating factors -- Local regulators of bone: IL-1, TNF, lymphotoxin, interferon-γ, IL-8, IL-10, IL-4, the LIF/IL-6 family, and additional cytokines -- Prostaglandins and bone metabolism -- Nitric oxide and other vasoactive agents -- Pt. II. Molecular mechanisms of metabolic bone diseases -- Molecular basis of PTH overexpression -- Familial benign hypocalciuric hypercalcemia and neonatal primary hyperparathyroidism -- Multiple endocrine neoplasia Type 1 -- The role of the RET protooncogene in multiple endocrine neoplasia Type 2 -- Systemic factors in skeletal manifestations of malignancy -- Local factors in skeletal malignancy -- Molecular basis of PTH underexpression -- Jansen's metaphysical chondrodysplasia and Blomstrand's lethal chondrodysplasia: two genetic disorders caused by PTH/PTHrP receptor mutations -- Pseudohypoparathyroidism -- Other skeletal diseases resulting from G protein defects: fibrous dysplasia of bone and McCune-Albright syndrome -- Osteogenesis imperfecta -- Hereditary deficiencies in Vitamin D action -- Oncogenic osteomalacia -- Osteopetrosis -- Hypophosphatasia: nature's window on alkaline phosphatase function in man -- Paget's disease of bone -- Genetic determinants of bone mass and osteoporotic fracture -- Pathophysiology of osteoporosis -- Evaluation of risk for osteoporosis fractures -- Pt. III. Pharmacological mechanisms of therapeutics -- Parathyroid hormone -- Calcium -- Calcium receptors as novel drug targets -- Bisphosphonates: mechanisms of action -- Fluoride in osteoporosis -- The pharmacology of estrogens in osteoporosis -- Vitamin D and analogs -- Molecular and clinical pharmacology of calcitonin -- Growth hormone and insulin-like growth factor-I treatment for metabolic bone diseases -- Anabolic steroid effects on bone in women -- Estrogen effects on bone in the male skeleton -- Mechanisms of exercise effects on bone -- Pt. IV. Methods in bone research -- Application of transgenic mice to problems of skeletal biology -- Use of cultured osteoblastic cells to identify and characterize transcriptional regulatory complexes -- Current methodlogic issues in cell and tissue culture -- Biochemical markers of bone metabolism -- Methods and clinical issues in bone densitometry and quantitative ultrasonometry -- Controversial issues in bone densitometry -- Macro- and microimaging of bone architecture -- Transilial bone biopsy -- Animal models in osteoporosis research -- Defining the genetics of osteoporosis: using the mouse to understand man.
edited by John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan.
Includes bibliographical references and index.