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Human chromosomes /

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Bibliographic Details
Main Author: Miller, Orlando J.
Other Authors: Therman, Eeva
Format: Book
Language:English
Published: New York : Springer, [2001]
Edition:Fourth edition.
Subjects:
Chromosomes, Human.
Cytogenetics.
Table of Contents:
  • Origins and directions of human cytogenetics
  • The mitotic cell cycle
  • DNA replication and chromosome reproduction
  • General features of mitotic chromosomes
  • The chemistry and packaging of chromosomes
  • Chromosome bands
  • Molecular correlates of chromosome bands
  • In situ hybridization
  • Main features of meiosis
  • Details of meiosis
  • Meiotic abnormalities: abnormal numbers of chromosomes
  • Abnormal phenotypes due to autosomal aneuploidy or polyploidy
  • Chromosome structural aberrations
  • The causes of structural aberrations
  • Syndromes due to autosomal deletions and duplications
  • Clinical importance of translocations, inversions, and insertions
  • Sex determination and the Y chromosome
  • The X chromosome, dosage compensation, and X inactivation
  • Phenotypic effects of sex chromosome imbalance
  • Fragile sites, trinucleotide repeat expansion, and the fragile X syndrome
  • Euploid chromosome aberrations, uniparental disomy, and genomic imprinting
  • Chromosome changes in cell differentiation
  • Somatic cell hybridization in cytogenetic analysis
  • Chromosome instability syndromes
  • DNA and gene amplification
  • Genome destabilization and multistep progression to cancer
  • Chromosomes and cancer: activation of oncogenes
  • Chromosomes and cancer: inactivation of tumor suppressor genes
  • Mapping human chromosomes
  • Genome plasticity and chromosome evolution
  • The future of human cytogenetics.