Molecular and genetic analysis of human traits /
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| Format: | Book |
| Language: | English |
| Published: |
Malden, MA :
Blackwell Science,
[2001]
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| Subjects: |
Table of Contents:
- The inheritance of simple Mendelian traits in humans
- Detecting Mendelian inheritance in humans
- Patterns of inheritance and examples
- The use of pedigrees to predict the results of matings
- Gathering data to test the mode of inheritance of a trait
- Inheritance of multiple traits: independent assortment and linkage
- Hereditary traits that do not show a simple Mendelian pattern
- Single-gene traits lacking a simple Mendelian pattern
- Quantitative traits
- Complex traits
- Localization of genes responsible for complex and quantitative traits
- Genome organization I
- Unexpressed DNA, repetitive and unique sequences
- Expressed DNA, genes and gene families
- Genome organization II
- Isolation and characterization of human genes
- The Human Genome Project
- Chromosomes and karyotypes
- The morphology of human chromosomes
- Chromosomal abnormalities
- Sex chromosomes
- The use of cytogenetics to localize genes
- How mutant alleles affect the phenotype
- Effects of mutations on the quality and quantity of protein products
- Mutations in soluble enzymes
- Mutations in structural proteins
- Mutations in transport proteins
- Mutations in regulatory proteins
- Mutations: damage and repair of DNA
- Endogenous (or spontaneous) DNA damage
- Exogenous (or environmental) DNA damage
- DNA repair systems
- Mutation rates
- Somatic mutations and mosaicism
- Cancer: a genetic disease
- The cell cycle under control
- Cancer cells
- Oncogenes
- Tumor suppressor genes
- Mutations and other changes that alter the function of cancer genes
- Genetic instability
- Invasiveness
- Cellular immortality and telomeres
- Genetic counseling
- Prenatal, neonatal, childhood, and adult genetic testing
- Actual risk and perceived risk.