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Molecular genetics in surgical oncology /

Bibliographic Details
Main Author: Moley, Jeffrey F.
Other Authors: Kim, Steve H.
Format: Book
Language:English
Published: Austin : R.G. Landes, 1994.
Series:Medical intelligence unit.
Subjects:
Neoplasms > genetics.
Neoplasms > surgery.
Tumor Cells, Cultured.
Table of Contents:
  • Overview of cancer genetics
  • Background: chromosomes, DNA and RNA
  • Chromosome number and nomenclature
  • DNA and RNA structure and nomenclature
  • Composition of the genome, pseudogenes, non-coding sequences
  • Molecular genetic techniques
  • Oncogenes, tumor suppressor genes, and programmed cell death
  • Oncogenes
  • Programmed cell death
  • Tumor suppressor genes
  • Metastasis
  • Gene products which alter cell-cell and cell-matrix interactions
  • Matrix degradation mechanisms
  • Tumor cell migration and angiogenesis.
  • Transgenic technology
  • Molecular basis of transgenics
  • Technical aspects of making transgenic mice
  • Transgenics in immunology
  • Transgenics in molecular oncology
  • Molecular genetics of tumors commonly treated by the surgical oncologist
  • Colorectal cancer
  • Breast cancer
  • Sarcoma
  • Esophageal cancer
  • Pancreatic cancer
  • Melanoma
  • Applications: prophylactic surgery for MEN 2 gene carriers
  • MEN syndromes
  • Genetic testing.