Cardiovascular drug development : protocol design and methodology /

Bibliographic Details
Other Authors:	Borer, J. S. (Jeffrey S.), Somberg, John C.
Format:	Book
Language:	English
Published:	New York : M. Dekker, [1999]
Series:	Fundamental and clinical cardiology ; 35.
Subjects:	Cardiovascular Agents > Congresses. Clinical Trials as Topic > Congresses. Drug Approval > Congresses.

Table of Contents:

Drug discovery and development
Development of congestive heart failure therapy
Background therapy in congestive heart failure studies
Congestive heart failure trial design
Angiostensin converting enzyme inhibitors for mortality reduction in congestive heart failure: Should approval be granted for a class effect?
Sudden death in congestive heart failure trials
Panel discussion
Development of antihypertensive therapy
Antihypertensive clinical trials
Calcium channel blockers: safety issues
Panel discussion
Development of antiarrhythmic drug therapy
Antiarrhythmics: indications, claims, and trial design
Supraventricular tachycardia drugs and trial design issues
Antiarrhythmic trials: update
Inter-ethnic differences in the susceptibility to drug-induced QT interval prolongation and torsade de pointes
Panel discussion
Development of antilipid and anti-ischemic therapy
Antilipid trial endpoints
Natural history endpoints and angina trials
Development of antiplatelet drugs
Panel discussion
Conclusion
Future directions of cardiovascular drug development.