Mechanism of steroid hormone regulation of gene transcription /

Bibliographic Details
Main Author: Tsai, Ming-Jer
Other Authors: O'Malley, Bert W.
Format: Book
Language:English
Published: Austin : R.G. Landes Co., 1994.
Series:Molecular biology intelligence unit.
Subjects:
Table of Contents:
  • Nuclear hormone receptor superfamily / Aria Baniahmad, Thomas P. Burris, Ming-Jer Tsai
  • Functional domains and modular structure of nuclear hormone receptors
  • Diseases associated with mutations in nuclear hormone receptors
  • Evolution of the nuclear hormone receptor superfamily
  • Nuclear receptor: DNA interactions / Austin J. Cooney, Sophia Y. Tsai
  • Historical perspective
  • Hormone response elements
  • Ligand dependence of DNA binding
  • Physical structure of the nuclear receptor DNA-binding domain.
  • Functional subdomains of the DNA-binding domain
  • Ligand-binding domain dimerization function
  • Mechanisms of target gene activation by steroid hormone receptors: insights from cell-free transcription systems / Milan Bagchi
  • RNA polymerase II transcription machinery
  • Components of a cell-free transcription system
  • Reconstitution of steroid receptor-regulated gene transcription system
  • Development of a steroid hormone-dependent cell-free transcription system
  • Role of steroid receptors in the formation of preinitation complex for transcription.
  • Interactions of receptors with the components of Pol II core transcription machinery
  • Mechanism of ligand activation / George Allan
  • Heat shock protein dissociation
  • Nuclear translocation
  • Dimerization and DNA binding
  • Phosphorylation
  • Conformational changes
  • Hormones and anti-hormones
  • Current model of steroid hormone action
  • Receptor phosphorylation / Nancy L. Weigel
  • Phosphorylation of steroid receptor family members
  • Kinases and receptor phosphorylation
  • Effect of phosphorylation on receptor functions.
  • Effect of modulators of kinases and phosphatases on transcriptional activation of steroid receptor family members
  • Orphan receptors: structure and function relationships / Orla M. Conneely, Bert W. O'Malley
  • General structural features common to orphan and lignad-activated nuclear receptors
  • Complexity of the nuclear receptor superfamily
  • Structural requirements for interaction of orphan receptors with enhancer DNA elements
  • Identification of target genes regulated by orphan receptors.
  • Nuclear receptor activation pathways
  • Ligand-independent activation of nuclear receptors
  • Constitutive transactivation by nuclear receptors
  • Nuclear receptors in development and differentiation / Beat Lutz ... [et al.]
  • Mechanisms of ecdysone action in drosophila development
  • Retinoids in the axial organization of the vertebrate embryo
  • Nuclear receptors in the developing nervous system.