P2 purinoceptors : localization, function and transduction mechanisms.

Bibliographic Details
Other Authors: Chadwick, Derek, Goode, Jamie
Format: Book
Language:English
Published: Chichester ; New York : Wiley, 1996.
Series:Ciba Foundation symposium ; 198.
Subjects:
Table of Contents:
  • P2 purinoceptors: historical perspective and classification 1
  • Discussion
  • The diadenosine polyphosphate receptors: P2D purinoceptors
  • P2T purinoceptors: ADP receptors on platelets
  • P2Z purinoceptors
  • P2X receptors: a third major class of ligand-gated ion channels
  • P2 purinoceptors and pyrimidinoceptors of catecholamine-producing cells and immunocytes
  • Trophic actions of extracellular ATP on astrocytes, synergistic interactions with fibroblast growth factors and underlying signal transduction mechanisms.
  • Trophic roles of P2 purinoceptors in central nervous system astroglial cells
  • Transduction mechanisms of P2Z purinoceptors
  • The diverse series of recombinant P2Y purinoceptors
  • Molecular modelling of P2Y purinoceptors
  • P2U purinoceptors: cDNA cloning, signal transduction mechanisms and structure-function analysis
  • Functional properties of native and cloned P2X receptors
  • ATP as a co-transmitter with noradrenaline in sympathetic nerves--function and fate.
  • ATP release and its prejunctional modulation
  • Distribution of purinoceptors
  • ATP as a neurotransmitter
  • Involvement of distinct receptors in the actions of extracellular uridine nucleotides
  • Features of P2X receptor-mediated synapses in the rat brain: why doesn't ATP kill the postsynaptic cell?
  • P2 purinoceptors in the immune system
  • Purinoceptors and the pancreas
  • Challenges in developing P2 purinoceptor-based therapeutics
  • Summing-up.