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Thermodynamic theory of site-specific binding processes in biological macromolecules /

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Bibliographic Details
Main Author: Di Cera, Enrico
Format: Book
Language:English
Published: Cambridge, [England] ; New York : Cambridge University Press, 1995.
Subjects:
Thermodynamics.
Binding Sites.
Macromolecular Substances.
Ligands.
Protein Binding.
Table of Contents:
  • Statistical thermodynamic foundations
  • Postulates and basic ensembles
  • The generalized ensemble
  • The laws of thermodynamics
  • Fluctuations
  • Simple models for energy transition
  • Simple models for binding
  • Global binding processes
  • The reference system
  • Cooperative binding
  • Properties of the binding curve
  • Properties of the binding capacity
  • Linkage effects: the reference cycle
  • Linkage effects: general treatment involving two ligands
  • Local binding processes
  • The reference cycle and site-specific cooperativity.
  • Contracted partition functions
  • Thermodynamic basis of site-specific effects
  • Properties of the binding curve in the local description
  • Properties of the binding capacity in the local description
  • Specific cases and applications
  • The case N = 2
  • The case N = 3
  • The case N = 4
  • Site-specific properties of hemoglobin
  • Site-specific binding curves from global properties of structurally perturbed systems
  • Pairwise coupling
  • Site-specific effects in ising networks.
  • The transition modes
  • A combinatorial model for molecular recognition
  • Site-specific effects in ising networks-- The probe theorem.