Molecular basis of autoimmune hepatitis /
| Other Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Austin :
R.G. Landes,
[1996]
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| Series: | Molecular biology intelligence unit.
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| Subjects: |
Table of Contents:
- 1. Historical overview
- Early desciptions of the disease
- Morphology and teminology
- Immunological and immunogenetic features of AIH
- Pathogenesis
- Therapy
- International agreement on diagnostic criteria
- 2. Nuclear antigens
- Introduction
- Histones
- DNA
- Nuclear lamins
- Other nuclear antigens
- Future consideration
- 3. Cytoskeletal Antigens
- Introduction
- Smooth muscle antibody (SMA)
- Anti-intermediate filament antibodies
- Antimicrotubule antibodies
- Antilamin antibodies
- Future perspective.
- 4. Cytoplasmic antigen
- Introduction
- Autoantibodies to microsomal antigens of the liver
- Liver-kidney microsomal antibodies type 1
- Liver-kidney microsomal antibodies type 2 (LKM2) and cytochrome P450 IIC9
- UDP-glucuronosyltransferase
- and microsomal autoantibodies (LKM3) in hepatitis d
- Autoantibodies against cytosolic components
- Conclusions and outlook
- Hepatocellular membrane antigens
- Background
- Liver membrane antigen
- Sulfatide (cerebroside sulfate)
- Human hepatocyte plasma membrane(HHPM) antigen.
- Liver-specific membrane Lipoprotein
- The asialoglycoprotein receptor(ASGPR)
- Immune reactions against the asialoglycoprotein receptor
- Concluding remarks
- 6. The immunogenetics of autaoimmune hepatitis in caucasoids
- Introduction
- Genetic organization of the MHC
- Molecular structure of HLA class I and class II molecules
- Clinical studies
- Possible mechanisms of HLA-encoded susceptibility to AIH
- Susceptibility versus Severity
- Directions for future studies
- 7. Immunogenetics of autoimmune hepatitis in Japanese.
- Introduction
- Characteristics of autoimmune hepatitis in Japan
- HLA phenotypes in Japanese AIH patients
- HLA DNA typing in AIH
- Conclusion: classifcation of AIH by HLA
- 8. Pathogenetic mechanism: evidence for human studies
- Introduction
- Impaired immunoregulation
- Afferent component of the autoimmune attack
- Efferent component autoimmune attack
- T cell cloning
- Summary of current knowledge
- Future research
- The german animal models of autoimmune hepatitis
- Introductiion
- Chronic hepatitis in rabbits.
- Murine experimental autoimmune hepatitis (EAH)
- Concanavalin A induced hepatitis
- Lessons learned
- Future consideration
- 10. The Japanese animal models of autoimmune hepatitis
- Introduction
- Experimental autoimmune hepatitis (EAH) in Japan
- Other models
- Consideration for the future
- 11. Immunosuppressive drug mechanisms
- Introduction
- Developement of immunosuppressive regimens
- Mechanisms of corticosteroid action
- Metabolism and mechanism of antipurine action
- Action of corticosteroids and azathioprine in AIH
- Other immunosuppressants
- Future consideration.