Gene targeting protocols /

Bibliographic Details
Other Authors: Kmiec, Eric
Format: Book
Language:English
Published: Totowa, N.J. : Humana Press, [2000]
Series:Methods in molecular biology (Clifton, N.J.) ; v. 133.
Subjects:
Table of Contents:
  • Nucleic acid transfer using cationic lipids
  • Optimizing polyethylenimine-based gene transfer into mammalian brain for analysis of promoter regulation and protein function
  • Gene transfer and drug delivery by electronic pulse delivery: a nonviral delivery approach
  • Strategies for improving the frequency and assessment of homologous recombination
  • Effective gene transfer using viral vectors based on SV40
  • Rapid generation of isogenic mammalian cell lines expressing recombinant transgenes by use of Cre recombinase
  • Site-directed alteration of genomic DNA by small-fragment homologous replacement
  • Mutation correction by homologous recombination with an adenovirus vector
  • Site-specific targeting of DNA plasmids to chromosome 19 using AAV Cis and Trans sequences
  • Adeno-associated virus based gene therapy in skeletal muscle
  • Rapid establisment of myeloma cell lines expressing Fac(Tac)-protamine, a targetable protein vector, directed against high-affinity α-chain of human interleukin-2 receptor
  • EBV-derived episomes to probe chromatin structure and gene expression in human cells
  • Triplex-directed site-specific genome modification
  • Use of quantitative ligation-mediated polymerase chain reaction to detect gene targeting by alkylating oligodeoxynucleotides
  • Gene targeting in plants via site-directed mutagenesis
  • Antisense oligonucleotides as modulators of pre-mRNA splicing.