The status of alternative methods in toxicology /
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| Format: | Book |
| Language: | English |
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Cambridge, UK :
Royal Society of Chemistry,
[1995]
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| Subjects: |
Table of Contents:
- Regulatory and market implications
- International and national legislation
- OECD
- EU
- USA
- Social and economic background
- Ethical issues
- Data banks on alternatives to animal testing
- Practical and financial considerations
- Market size
- State-of-the-Art
- Genotoxicity/mutagenicity
- Genotoxicity data bases
- Methods in preparation
- Cytotoxicity
- Acute toxicity
- Eye irritation
- Cytotoxicity tests
- Non-biological physico-chemical tests
- Morphology-based assays.
- Isolated enucleated eyes or eye parts
- Human skin equivalent models
- Validation studies
- Quantitative structure-activity relationships
- Skin irritation
- Cytotoxicity tests
- Non-biological physico-chemical tests
- Skin slices
- Skin organ culture
- Quantitative structure-activity relationships
- Phototoxicity and photoallergenicity
- Target organ toxicity
- Hepatotoxicity
- Nephrotoxicity
- Lung toxicity
- Intestinal toxicity
- Cardiovascular toxicity.
- Haemotoxicity
- Target system toxicity
- Neurotoxicity
- Immunotoxicity
- Reproductive toxicity
- Effects on the male reproductive system
- Effects on the female reproductive system
- Embryotoxicity and teratogenicity
- Mammalian test systems
- Non-mammalian test systems
- Quantitative structure-activity relationships
- Dermal absorption
- Structure-activity relationships
- Genotoxicity and carcinogenicity
- Acute toxicity
- Skin and eye irritation
- Sensitization
- Target organ toxicity
- Teratogenicity.
- Validation of in vitro toxicity tests
- Reliability
- Validation
- Classification, labelling, and risk assessment
- Future needs
- Concluding remarks.