Human protein metabolism /
| Main Author: | |
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| Format: | Book |
| Language: | English |
| Published: |
New York :
Springer,
[1999]
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| Subjects: |
Table of Contents:
- Importance of protein dynamics
- Protein structure and the concept of protein turnover
- Rapid turnover of proteins facilitates rapid changes in protein concentrations
- Protein turnover is necessary to maintain protein quality
- Appendix
- Basic mechanisms of protein turnover
- Protein degradation
- Disposal of amino acids generated by proteolysis
- Protein synthesis
- Posttranslational modifications
- Mitochondrial protein synthesis
- Potential sites of regulation of protein turnover
- Methods for studying protein metabolism in humans
- Measuring changes in protein mass of the body
- Whole-body protein turnover
- Whole-body protein oxidation
- Protein metabolism in specific organs or limbs
- Incorporation of tracer into tissue proteins or specific proteins
- Polyribosome abundance as a measure of protein synthesis
- 3-methylhistidine excretion as a measure of myofibrillar proteolysis
- Markers of collagen metabolism
- Radioiodinated protein administration to measure protein half-life
- Analytical methods
- Normative data from infancy to old age
- Whole-body N balance
- Protein oxidation
- Whole-body protein turnover
- Protein turnover in organs and tissues
- Turnover of specific proteins
- Nutritional influences
- Acute responses to meals
- Starvation
- Very-low-energy diets
- Malnutrition
- High energy intake
- High protein intake
- Summary of effects of energy and protein on whole-body protein metabolism
- Endocrine, paracrine, and autocrine regulation
- Insulin
- Growth hormone
- Insulin-like growth factor-I (IGF-1)
- Other growth factors
- Androgens
- Ovarian steroids
- Epinephrine
- Cortisol
- Thyroid hormones
- Glucagon
- Cytokines
- Prostaglandins
- Regulation by metabolic substrates
- Amino acids
- Glucose and its metabolites
- Triglycerides, fatty acids, and ketone bodies
- Physical activity
- Effect of inactivity on protein metabolism
- Effect of increased physical activity on protein metabolism
- Topics of clinical interest
- Acidosis
- Alcoholism
- Arthritis
- Cancer
- Cirrhosis
- Diabetes
- Glucocorticoid therapy
- Heart disease
- HIV infection and AIDS
- Infection
- Muscular dystrophies
- Obesity
- Parenteral and enteral nutrition
- Pregnancy and lactation
- Renal failure
- Tissue injury (trauma, surgery, burns).