Apoptosis and cancer chemotherapy /

Bibliographic Details
Other Authors: Hickman, John A., Dive, Caroline
Format: Book
Language:English
Published: Totowa, N.J. : Humana Press, [1999]
Series:Cancer drug discovery and development ; 5.
Subjects:
Table of Contents:
  • Does apoptosis contribute to tumor cell sensitivity to anticancer agents?
  • p53, apoptosis and chemotherapy
  • The role of p53 in chemosensitivity
  • Function of the p53 gene family: a holistic perspective
  • Mismatch repair deficiencty, apoptosis, and drug resistance
  • Involvement of c-Abl tyrosine kinase in apoptotic response to anticancer agents
  • Bcl-2 family proteins: relative importance as determinants fo chemoresistance in cancer
  • Bax, a death effector molecule: its role in development and oncogenesis
  • Bax, a proapoptotic protein forming channels in mitochondria
  • Mechanism of action of the proapoptotic gene Bak
  • Killers or clean-up crews: How central are the central mechanisms of apoptosis?
  • Role of CD95 (APO-1/Fas) system in chemotherapy
  • Insulin-like growth factor-1 receptor as a target for anticancer therapy
  • Drug resistance and the survival niche: survival signals combine to suppress drug-induced apoptosis in B-lymphoma cells
  • Chemotherapy, tumor microenvironment, and apoptosis
  • Molecular regulation and therapeutic implications of cell death in prostate cancer
  • Chemotherapy and apoptosis in the ovary: cancer treatment comes with a price
  • Role of Bel-2 family members in homeostasis, in toxicology in normal intestine, and for prognosis of colonic carcinomas
  • Apoptosis and breast cancer
  • Role of apoptosis in human neuroblastomas
  • Response of testicular-tumors to chemotherapy: relative role of drug-DNA interactions and apoptosis
  • Concluding remarks: Has the information explosion on apoptosis affected clinical practice?