Ex vivo cell therapy /
| Other Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
San Diego :
Academic Press,
[1999]
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| Subjects: |
Table of Contents:
- Introduction / Robert E. Nordon, Klaus Schindhelm
- Transcriptional control of hematopoiesis / L. Robb, A.G. Elefanty, C.G. Begley
- SCL: a master hematopoietic regulator gene identified via chromosome translocation
- SCL in normal hematopoiesis
- LMO2: another partner for SCL
- The GATA family of transcriptional factors
- AML-1 and CBFβ are required for definitive hematopoiesis
- Additional examples of defective hematopoiesis: MYB and PU.1 knockouts
- Lineage-specific defects: EKLF and NF-E2 knockouts
- Ikaros and E2A: examples of key transcription factors in lymphopoiesis
- Conclusions
- Cell signaling by hematopoietic growth factor receptors / R. Starr, N.A. Nicola
- Introduction
- The JAK/STAT signal transduction pathways
- Ras activation pathway
- Signal transduction through phospholipase C
- Inhibitory pathways
- Pathways leading to cell death (apoptosis) or survival
- TGF-β family signaling
- Some other pathways
- Summary
- Influence of cytokines and adhesion molecules on hematopoietic stem cell development / P.J. Simmons, D.N. Haylock, J.-P. Lévesque
- Introduction
- Primitive hematopoietic progenitor cells require multiple cytokines for proliferation
- Cytokines which act on primitive HPC: Flt3-ligand and thrombopoietin
- What then for ex vivo manipulation of hematopoietic stem cells?
- Adhesive interactions and their role of hematopoietic regulation
- The cross-talk between integrins and cytokine receptors
- Integrins and hematopoietic leukemias: the example of chronic myelogenous leukemia (CML)
- Mucin-like molecules: an emerging family of cell adhesion molecules expressed by hematopoietic progenitor cells
- Outside-in signaling through mucin-like molecules on hematopoietic progenitor cells: negative regulators of hematopoiesis?
- Allogeneic hematopoietic stem cell transplantation / P.A. Rowlings
- Introduction
- Indications for allogeneic hematopoietic stem cell transplants
- Donor and tissue sources of hematopoietic stem cells
- Results of allogeneic hematopoietic stem cell transplants
- Allogeneic donor lymphocyte infusions
- Adverse events in long-term survivors
- Autologous stem cell transplantation / Uwe Hahn, L. Bik To
- Introduction and historical background
- Hematological malignancies
- Solid tumors
- Peripheral blood stem cell transplantation
- Malignant contamination of autologous grafts
- Future developments
- Cord blood stem cell transplantation / Marcus R. Vowels
- Introduction
- Unrelated bone marrow donor transplants
- Cord blood
- Related cord blood transplants
- Unrelated cord blood transplants
- Unrelated cord blood banking
- Advantages and disadvantages of cord blood
- Conclusions and future progress
- Reconstitution of immunity by adoptive immunotherapy with T cells / Stanley R. Riddell ... [et al.]
- Introduction
- Biological and molecular basis of T-cell recognition of viruses and tumors
- Immunologic memory mediated by αβ T cells
- Mechanisms of evasion of T-cell responses by viruses and tumors
- Methods of selection of antigen-specific T-cell clones
- Genetic modification of T cells to improve the safety and/or efficacy of adoptive immunotherapy
- Clinical studies of cellular adoptive immunotherapy for viruses and virus-induced malignancies
- Potential for adoptive immunotherapy with tumor-reactive T cells
- Exogenous gene transfer into lymphoid and hematopoietic progenitor cells / Lun Quan Sun, Michelle Miller, Geoff Symonds
- Introduction
- Vector design
- Packaging cell lines
- Gene transfer into lymphoid cells
- Gene transfer into hematopoietic progenitor cells
- Process development for ex vivo cell therapy / Charles Dowding ... [et al.]
- Introduction
- Clinical utility of transplantation of purified HSCs
- Regulation of ex vivo cell processing
- Quality assurance
- Process development
- Cell separation / Robert E. Nordon, Klaus Schindhelm
- Introduction
- Cell separation methods
- Rationale for cell selection
- Environmental requirements of hematopoietic progenitor cells in ex vivo expansion systems / Peter W. Zandstra, Connie J. Eaves, James M. Piret
- Introduction
- Potential applications of cell expansion as a cellular therapy
- Development of hematopoietic cell culture systems suitable for clinical scale-up
- Refinement of bioreactor operating parameters
- Receptor stimulation and medium cytokine depletion
- Ex vivo hematopoietic cell expansion for bone marrow transplantation / Ramkumar Mandalam, Manfred Koller, Alan Smith
- Introduction
- Hematopoietic stem cell transplantation
- Definition of a biological process for HSC production
- Design of a device to implement the biological process
- Integration of device into a novel GMP cell production system
- Biological performance of the automated AastromReplicell system
- Implementation of the process and AastromReplicell system in clinical trials
- Gene delivery technology: nonviral and viral vector systems / Mitch Raponi, Geoff Symonds
- Introduction
- Nonviral gene delivery
- Viral delivery systems
- Summary and future directions / Robert E. Nordon, Klaus Schindhelm
- Introduction
- Extrinsic or intrinsic manipulation of hematopoietic cell growth and differentiation
- Hematopoietic cell graft engineering
- Core technologies required for delivery of ex vivo cell therapy
- Future directions.