Bioadhesive drug delivery systems : fundamentals, novel approaches, and development /
| Other Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York :
Marcel Dekker,
[1999]
|
| Series: | Drugs and the pharmaceutical sciences ;
v. 98. |
| Subjects: |
Table of Contents:
- I. Fundamentals of bioadhesion
- Definitions, mechanisms, and theories of bioadhesion
- The role of water movement and polymer hydration in mucoadhesion
- A rheological approach to explain the mucoadhesive behavior of polymer hydrogels
- Functional histology of epithelia relevant for drug delivery: respiratory tract, digestive tract, eye, skin, and vagina
- Biochemical and functional aspects of mucus and mucin-type glycoproteins
- II. Methods of evaluating bioadhesive interactions
- Adaptation of a microbalance to measure bioadhesive properties of microspheres
- Novel magnetic technique to measure bioadhesion
- Principles of skin adhesion and methods for measuring adhesion of transdermal systems
- Force microscopy of cells to measure bioadhesion
- Direct measurement of molecular-level forces and adhesion in biological systems
- A centrifugation method for measurement of two-dimensional binding characteristics of receptor-ligand interaction
- III. Novel concepts and strategies for bioadhesive drug delivery systems
- Multifunctional polymers for the peroral delivery of peptide drugs
- Chitosan and chitosan derivatives as absorption enhancers for peptide drugs across mucosal epithelia
- Plant lectins for oral drug delivery to different parts of the gastrointestinal tract
- Bacterial invasion factors and lectins as second-generation bioadhesives
- Novel PEG-containing acrylate copolymers with improved mucoadhesive properties
- Bioadhesive, bioerodible polymers for increased intestinal update
- IV. Development issues of bioadhesive drug delivery systems: products and clinical trials
- Novel formulation approaches to oral mucoadhesive drug delivery systems
- Bioadhesive formulations for nasal peptide delivery
- Development of bioadhesive buccal patches
- Vaginal delivery of calcitonin by hyaluronic acid formulations
- Ocular bioadhesive drug delivery systems
- Bioadhesive preparations as topical dosage forms.