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Drug-DNA interaction protocols /

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Bibliographic Details
Other Authors: Fox, Keith R.
Format: Book
Language:English
Published: Totowa, NJ : Humana Press, [1997]
Series:Methods in molecular biology (Clifton, N.J.) ; v. 90.
Subjects:
DNA > drug effects.
DNA > pharmacology.
Drug Interactions.
DNA Footprinting > methods.
Polymerase Chain Reaction > methods.
DNA Probes.
DNA-Binding Proteins.
Table of Contents:
  • DNase footprinting / Keith R. Fox
  • Quantitative DNA footprinting / James C. Dabrowiak, Jerry Goodisman, and Brian Ward
  • Uranyl photoprobing of DNA structures and drug-DNA complexes / Niels Erik Mollegaard and Peter E. Nielsen
  • Diethylpyrocarbonate and osmium tetroxide as probes for drug-induced changes in DNA conformation in vitro / Christian Bailly and Michael J. Waring
  • Footprinting studies with nucleosome-bound DNA / Philip M. Brown and Keith R. Fox.
  • A Gel mobility shift assay for probing the effect of drug-DNA adducts of DNA-binding proteins / Suzanne M. Cutts ... [et. al.]
  • An Oligonucleotide crosslinking assay for the analysis of individual drug-binding sites / Suzanne M. Cutts ... [et. al.]
  • DNA polymerase inhibition assay (PIA) for the detection of drug-DNA interactions / Thomas P. Dooley and Katherine L. Weiland
  • Transcriptional footprinting of drug-DNA interactions / Don R. Phillips and Carleen Cullinane
  • Determination of the DNA sequence specificity of alkylation damage using cleavage-based assays / John A. Harley and Michael D. Wyatt.
  • PCR-based methods for detecting DNA damage and its repair at the subgene and single nucleotide levels in cells / Keith A. Grimaldi and John A. Hartley
  • Analysis of DNA-binding antibodies / Jeremy S. Lee, Laura J.P. Latimer, and Jamshid Tanha
  • Immunofluorescent staining of chromosomes with DNA-binding antibodies / Jeremy S. Lee, Laura J.P. Latimer, and Gary D. Burkholder
  • Optical absorbance and fluorescence techniques for measuring DNA-drug interactions / Terence C. Jenkins
  • Evaluation of drug-nucleic acid interactions by thermal melting curves / W. David Wilson ... [et. al.].
  • Electric dichroism / Dietmar Porschke
  • Calorimetric techniques for studying drug-DNA interactions / Harry P. Hopins, Jr
  • Methods for the studies of drug dissociation from DNA / Fu-Ming Chen.