http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
xvii, 418 pages : illustrations ; 25 cm.
1. Membrane transport mechanism -- P-glycoprotein-mediated multidrug resistance: experimental and clinical strategies for its reversal -- Multidrug resistance associated with overexpression of MRP -- 2. Resistance to alkylating agents -- Mechanisms of resistance to alkylating agents -- Glutathione S- transferases -- Role of DNA repair in resistance to drugs that alkylate 06 of guanine -- 3. Resistance to microtubule active drugs -- Paclitaxel (Taxol): mechanisms of resistance -- 4. Resistance to antimetabolites.
Mechanisms of clinical resistance to 5-fluorouracil chemotherapy -- Antifolates: current developments -- Human immunodeficiency virus replication in the presence of antiretroviral drugs: analogies to antineoplastic drug resistance -- 5. Topoisomerases -- Cellular resistance to topoisomerase poisons -- 6. Resistance to endocrine therapies -- Acquisition of an antiestrogen resistant phenotype in breast cancer: role of cellular and molecular mechanism -- Androgen receptor mutations in prostate cancer -- 7. Resistance to retinoids.
Retinoids in clinical cancer therapy -- 8. Novel mechanisms and approaches -- Apoptosis and cancer chemotherapy -- Interaction of chemotherapy and biological response modifiers in the treatment of melanoma -- Multifunctional modulators of drug resistance.
Includes bibliographical references and index.