rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Genes and aging
  name:
    name part: Kanungo, M. S. (Madhu Sudan)
    name part: 1927-
    role:
      role term: creator
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: enk
    date issued: 1994
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xii, 322 pages : illustrations ; 24 cm.
  table of contents: Phases in life span -- Development -- Reproductive phase -- Senescence -- Functional changes during aging -- Life span -- Longevity -- Evolution of aging -- Cell death -- Science of aging -- Phenotypic changes during aging -- Changes in levels of enzymes -- Kinetics and other parameters of enzymes -- Changes in multiple forms of proteins during aging -- Induction of enzymes -- Changes in collagen -- Turnover of proteins -- Modifications of bases -- Changes in RNA -- Transfer RNA -- Ribosomal RNA -- Messenger RNA -- Turnover of RNA -- DNA polymerases -- Chromatin -- Histones -- H1 histone -- Core histones: H2A, H2B, H3, and H4 -- H5 histone -- Protamines -- Histone genes -- Histone variants -- Modifications of chromosomal proteins -- Acetylation -- Phosphorylation -- Poly(ADP)-ribosylation -- Methylation -- Ubiquitination -- Synthesis and turnover of histones -- Nonhistone chromosomal proteins -- Structure of chromatin -- DNA-histone interactions -- Higher-order structure of chromatin -- Interphase chromosomes -- Metaphase chromosomes -- Chromatin structure and transcription -- Active and inactive chromatin -- Protein-coding genes -- Transfer RNA and ribosomal RNA genes -- Age-related changes in chromatin structure and function -- Eukaryotic genes -- Exons and introns -- Transcription -- RNA polymerase II -- Transcription factors -- Processing of pre-mRNA, pre-tRNA and pre-rRNA -- Splicing of pre-mRNA -- Splicing of pre-rRNA and pre-tRNA -- Structure of eukaryotic genes -- DNA sequences that control transcription -- Cis-acting elements -- Repeated DNA sequences -- DNA-binding proteins -- Helix-turn-helix (HTH) -- Helix-loop-helix (HLH) -- Zinc finger -- Leucine zipper -- Modifications of bases in DNA -- Methylation -- Other modifications -- Mechanism of action of regulatory elements in genes -- Factors that regulate transcription -- Regulation of gene expression -- Changes in gene expression during aging -- Programmed cell death -- Gene expression in vivo -- Genes fo…
  table of contents: Genes in X chromosomes -- Increased activation of other genes -- Amyloid precursor protein gene and Alzheimer's disease -- Methylation -- Alterations in mitochondrial DNA -- Editing and splicing of RNA -- Editing of mRNA -- Alternative splicing of pre-RNA -- Telomere DNA -- Theories of aging -- Somatic mutation theory -- DNA damage and repair -- Error theory -- Disposable soma theory -- Dysdifferentiation hypothesis -- Gene regulation theory -- Deterioration of function -- Determination of life span -- Conclusions and future prospects.
  note: M.S. Kanungo.
  note: Includes bibliographical references (pages 290-319) and index.
  subject:
    topic: Aging
    topic: genetics
  subject:
    topic: Cellular Senescence
  classification: QP86 .K335 1994
  classification: 612.6/7
  identifier: 0521382998 (hardback)
  identifier: 93002766
  record info:
    record content source: DLC
    record creation date: 930113
    record change date: 20191202143839.0
    record identifier: in00004486753