http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Phases in life span -- Development -- Reproductive phase -- Senescence -- Functional changes during aging -- Life span -- Longevity -- Evolution of aging -- Cell death -- Science of aging -- Phenotypic changes during aging -- Changes in levels of enzymes -- Kinetics and other parameters of enzymes -- Changes in multiple forms of proteins during aging -- Induction of enzymes -- Changes in collagen -- Turnover of proteins -- Modifications of bases -- Changes in RNA -- Transfer RNA -- Ribosomal RNA -- Messenger RNA -- Turnover of RNA -- DNA polymerases -- Chromatin -- Histones -- H1 histone -- Core histones: H2A, H2B, H3, and H4 -- H5 histone -- Protamines -- Histone genes -- Histone variants -- Modifications of chromosomal proteins -- Acetylation -- Phosphorylation -- Poly(ADP)-ribosylation -- Methylation -- Ubiquitination -- Synthesis and turnover of histones -- Nonhistone chromosomal proteins -- Structure of chromatin -- DNA-histone interactions -- Higher-order structure of chromatin -- Interphase chromosomes -- Metaphase chromosomes -- Chromatin structure and transcription -- Active and inactive chromatin -- Protein-coding genes -- Transfer RNA and ribosomal RNA genes -- Age-related changes in chromatin structure and function -- Eukaryotic genes -- Exons and introns -- Transcription -- RNA polymerase II -- Transcription factors -- Processing of pre-mRNA, pre-tRNA and pre-rRNA -- Splicing of pre-mRNA -- Splicing of pre-rRNA and pre-tRNA -- Structure of eukaryotic genes -- DNA sequences that control transcription -- Cis-acting elements -- Repeated DNA sequences -- DNA-binding proteins -- Helix-turn-helix (HTH) -- Helix-loop-helix (HLH) -- Zinc finger -- Leucine zipper -- Modifications of bases in DNA -- Methylation -- Other modifications -- Mechanism of action of regulatory elements in genes -- Factors that regulate transcription -- Regulation of gene expression -- Changes in gene expression during aging -- Programmed cell death -- Gene expression in vivo -- Genes for enzymes -- Genes for other proteins -- Genes for acute-phase proteins -- Heat-shock protein genes -- Genes for structural proteins -- Oncogenes -- Transgenes -- Gene expression in vitro -- Dominant nature of cellular senescence -- Chromosome implicated in cellular senescence -- Proto-oncogenes and cellular senescence -- Response to heat stress -- Inhibitors of cellular proliferation -- Cause of senescence of fibroblasts -- Changes in gene expression -- Reactivation of genes in old age
Genes in X chromosomes -- Increased activation of other genes -- Amyloid precursor protein gene and Alzheimer's disease -- Methylation -- Alterations in mitochondrial DNA -- Editing and splicing of RNA -- Editing of mRNA -- Alternative splicing of pre-RNA -- Telomere DNA -- Theories of aging -- Somatic mutation theory -- DNA damage and repair -- Error theory -- Disposable soma theory -- Dysdifferentiation hypothesis -- Gene regulation theory -- Deterioration of function -- Determination of life span -- Conclusions and future prospects.
Includes bibliographical references (pages 290-319) and index.