Cover Image

Molecular and functional aspects of blood group antigens /

Bibliographic Details
Other Authors: Silberstein, Leslie E.
Format: Book
Language:English
Published: Bethesda, Md. : American Association of Blood Banks, 1995.
Subjects:
Blood Group Antigens > immunology.
Blood Group Antigens > genetics.
Blood Grouping and Crossmatching > methods.
Table of Contents:
  • 1. DNA testing of blood group polymorphisms
  • DNA basics
  • Overview of DNA analysis
  • DNA typing for HLA antigens
  • DNA typing for platelet-specific antigens
  • DNA typing for red cell antigens
  • 2. Chromosomal localization of human blood group genes
  • Methodology
  • Localization of human blood group genes
  • Future considerations
  • Summary
  • 3. Molecular basis for blood group function of carrier proteins
  • Blood group terminolgy
  • RBC membrane.
  • Molecular basis of blood group antigens and phenotypes
  • Function of proteins carrying blood group antigens
  • Function of carbohydrate antigens
  • Expression of blood group antigens requiring interaction
  • Expression of antigens carrier proteins in other cells
  • Conclusion
  • Note added in revision
  • 4. Blood groups and genetic concepts: ruminations
  • The foundation
  • The emergence of immunogenetics
  • Blood group inheritance and expression
  • Genetic linkage
  • Gene mapping
  • Mutation and polymorphism.
  • Population genetics
  • Manitobans
  • Whither blood group serology?
  • In the dusk of millennium
  • 5. Functional roles of blood group antigens
  • Serology, molecular biology and function
  • Physiologic roles of RBC antigens
  • RBC antigens as microbial receptors
  • Conclusions
  • 6. Epitopes of Rh D: Serology and molecular genetics
  • Quantitative variation in D expression
  • Partial D antigens and the epitopes of D
  • The molecular basis of the D antigen.
  • Conclusions
  • 7. The Human Genome Project: Update 1995
  • History
  • Goals of Human Genome Project
  • Strategies
  • Ethical, legal and social immplications
  • Summary.