The society of cells : cancer and control of cell proliferation /
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| Format: | Book |
| Language: | English |
| Published: |
Oxford : New York :
Bios Scientific Publishers ; Springer,
1999.
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Table of Contents:
- Cell proliferation: the background and the premises
- A brief history
- Understanding the control of cell proliferation
- The hierachical organizatin of nature
- Cell proliferation, cell nutrition and evolution
- Evolutionary perspective on the control of cell proliferation
- The role of nutrition on the control of cell proliferation
- The experimental evaluation of cell proliferation
- Fitting data into working hypotheses - The use and misuse of tritiated thymidine incorporation data
- Hypotheses for the control of cell proliferation
- Historical perspective
- Positive hypotheses
- Negative hypotheses
- Sex hormone-mediated control of cell proliferation
- Control of cell proliferation by estrogens
- Hypotheses
- Control of cell proliferation by androgens
- Cell proliferation and tissue differentiation
- The different meanings of 'differentiation'
- A hierachical perspective
- The elusive concept of stem cells
- The hemopoietic stem cells
- Proliferation of antibody-producing cells: a different perspective
- Introduction to carcinogenesis and neoplasia
- If normal cells beget normal cells, and neoplastic cells beget neoplastic cells, what causes normal cells to become neoplastic?
- Germ-line mutations and carcinogenesis
- Somatic mutations, cell proliferation, cell death, and the 'differentiation' hypothesis
- Are carcinogenesis and neoplasia cellular or tissue-based phenomena?
- The enormous complexity of cancer
- Hierarchical levels of complexity in cancer
- Facts and fantasies in carcinogenesis
- Experimental carcinogenesis: the lessons missed
- Foreign-body carcinogenesis
- Physical carcinogenesis
- Chemical carcinogenesis
- Viral carcinogenesis. But ... are viruses per se carcinogenic agents?
- On the uniqueness of the neoplastic cell
- Carcinogenesis in a flask
- Epilogue. Moving toward the integration of cell proliferation, carcinogenesis, and neoplasia into biology
- Ideology, silent assumptions, and operational definitions
- The university of proliferation as the default state of all cells
- Forerunners of the tissue organization field hypothesis
- On paradigm changes
- An intergrative approach of control of cell proliferation and carcinogenesis
- The impact of our reassessment
- And ... finally.