Basic molecular biology : essential techniques /

Bibliographic Details
Main Author: Darbre, Philippa D.
Format: Book
Language:English
Published: Chichester ; New York : Wiley, [1999]
Series:Essential techniques series.
Subjects:

MARC

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264 1 |a Chichester ;  |a New York :  |b Wiley,  |c [1999] 
264 4 |c ©1999 
300 |a xi, 193 pages ;  |c 22 cm. 
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490 1 |a Essential techniques series 
504 |a Includes bibliographical references and index. 
505 0 |a DNA structure -- Denaturation and renaturation (hybridization) of -- DNA -- RNA structure -- Enzymes used in molecular biology -- Restriction endonucleases -- DNA polymerases -- RNA polymerases -- Nucleases -- End-modification enzymes -- Ligases -- DNA cloning -- Setting up a molecular biology laboratory -- Preparation of DNA -- Methods available -- Protocols -- Preparation of cell pellet and cell lysis -- Phenol extraction of DNA -- Ethanol precipitation of DNA -- Removal of RNA by ribonuclease treatment -- Final purification steps -- Assessment of DNA concentration and DNA quality -- Preparation of RNA -- Methods available -- Protocols -- Preparation of cell pellet -- Preparation of cytoplasmic RNA -- Preparation of whole cell RNA by ultracentrifugation method -- Preparation of whole cell RNA by Chomczynski-Sacchi method -- Assessment of RNA concentration and RNA quality -- Selection of poly(A)* RNA -- Preparation of plasmid DNA -- Methods available -- Protocols -- Transformation of bacteria with plasmid -- Growth of bacteria and amplification of plasmid -- Small-scale preparation of plasmid DNA -- Large-scale preparation of plasmid DNA -- Isolation of cloned gene sequences -- DNA analysis by restriction enzyme digestion and Southern blotting -- Methods available -- Protocols -- Restriction endonuclease digestion -- Concentration of DNA by ethanol precipitation -- Agarose gel electrophoresis -- Southern blotting -- Radiolabeling of DNA probe -- Hybridization of blot -- Washing of blot -- 5'-end radiolabeling of DNA molecular weight markers -- DNA analysis by PCR -- Methods available -- Protocols -- PCR reaction -- Analysis of PCR products by agarose gel electrophoresis -- RNA analysis by Northern blotting -- Methods available -- Protocols -- Formaldehyde-agarose gel electrophoresis -- Northern blotting and hybridization to radiolabelled DNA probe -- RNA analysis by RNase protection -- Methods available -- Protocols -- Preparation of riboprobe -- RNase protection assay -- Analysis of products by polyacrylamide gel electrophoresis -- RNA analysis by RT-PCR and differential display -- Methods available -- Protocols -- RT-PCR reaction and analysis of products -- Differential display -- Analysis of protein-DNA interactions by gel shift assay -- Methods available -- Protocols -- Preparation of protein extract -- Gel shift assay -- Gene transfection -- Methods used -- Protocols -- Transient transfection -- Stable transfection -- Appendix A: recipes for routine solutions -- Appendix B: Sources of reagents and equipment. 
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