Oral antidiabetics /
| Other Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Berlin ; New York :
Springer-Verlag,
1996.
|
| Series: | Handbook of experimental pharmacology ;
v. 119. |
| Subjects: |
Table of Contents:
- Introduction
- Pathophysiology of type 2 diabetes mellitus
- Introduction
- Abnormalities of the gulcose-insulin feedback loop.
- Possible causal defects
- Role of associated obesity
- Dynamic interation between insulin action and insulin secretion
- Conclusions
- References
- Non-pharmacological management of non-insulin-dependent diabetes
- Dietary management
- Exercise
- References
- Sulfonylureas
- Sulfonylureas and related compounds: Chemistry and structure-activity relationships
- Introduction
- Sulfonylureas
- Sulfonylsemicarbazides
- Sulfonylaminopyrimidines
- Various nonmarketed compounds of interest
- Conclusions
- References
- Sulfonylureas: Physicochemical properties, analytical methods of determination and bioavailability
- Introduction
- Physical properties
- Ultraviolet spectrum
- Infrared spectrum
- Nuclear magnetic resonance spectrum
- Mass spectrum
- Color and identification reactions
- Stability and degradation
- Methods of analysis
- Chromatographic methods
- Bioavailability
- References.
- Mode of action of sulfonylureas
- Introduction
- Actions of pancreatic † cells
- Action on non-† cells in pancreatic islets
- Actions on neurons
- Actions on cardiac cells
- Actions on smooth muscle
- Actions on skeletal muscle
- Actions on miscellaneous cells
- Conclusions
- References
- Sulfonylureas: Pharmacokinetics in animal experiments
- Introduction
- Absorption of sulfonylurea derivatives after oral administration
- Distribution of sulfonylurea derivatives in the organism
- Accumulation of sulfonylurea derivatives in different organ systems
- Elimination of sulfonylurea derivatives
- Influence of other drugs on rate of metabolism and excretion of sulfonylurea drugs
- Possible implications of the results from animal experiments on the pharmacokinetics of sulfonylurea derivatives for clinical applications in humans
- References
- Toxicology of sulfonylureas
- Introduction
- Acute toxicology
- Chronic toxicology.
- Reproduction toxicology
- Mutagenicity
- Other toxicological studies
- Conclusions
- References
- Clinical pharmacology of sulfonylureas
- Pharmacodynamics
- Pharmacokinetics
- Safety and tolerance
- References
- Biguanides
- Chemistry and structure-activity relationships of biguanides.
- Introduction
- Chemistry
- Structure-activity relationships
- References
- Physicochemical properties and analytical methods of determination of biguanides
- Physical properties
- Quantitative determination in biological medium
- References
- Preclinical pharmacology of biguanides
- Introduction
- Absorption and distribution
- Efficacy
- General pharmacology
- Organ pharmacology
- Lipid metabolism
- Cellular effects
- Conclusions
- References
- Toxicology of biguanides
- Introduction
- General pharmacology and toxicology
- Acute and chronic toxicity
- Comparative evaluations and critical remarks
- References
- Clinical pharmacology of biguanides
- Introduction
- Pharmacodynamics
- Effects on metabolic pathways in human diabetes
- Indications
- Contraindications and precautions
- Combination therapy
- Pharmacokinetics
- Safety and tolerance
- Interactions
- References.
- Glucosidase inhibitors
- Chemistry and structure-activity relationships of glucosidase inhibitors
- Introduction
- Pseudoglucosylamines
- Polyhydroxypiperidines and polyhydroxypyrrolidines
- References
- Analytical methods of determination of glucosidase inhibitors
- Chromatographic techniques.
- Spectroscopic techniques
- References
- Pharmacology of glucosidase inhibitors
- Introduction
- Intestinal digestion of dietary di-, oligo- and polysaccharides by α-glucosidases
- Exploratory investigations on the feasability of α-glucosidase inhibition
- Secondary effects of glucosidase inhibitors
- References
- General pharmacology of glucosidase inhibitors
- Introduction
- Neuropharmacological studies
- Cardiovascular/respiratory studies
- Gastrointestinal function studies
- Haematological studies
- Antigenic, antiallergic and pulmonary activity
- Antibacterial, antimycotic and antiparasitic activity
- Other studies
- References
- Pharmacokinetics and metabolism of glucosidase inhibitors
- Introduction
- Acarviosin derivatives
- Valiolamine derivatives
- Deoxynojirimycin derivatives
- Comparative discussion
- References
- Toxicology of glucosidase inhibitors
- Acarbose
- Emiglitate
- Miglitol.
- Voglibose
- Castanospermine
- Common toxicological characteristics
- References
- Clinical pharmacology of glucosidase inhibitors
- Acarbose
- Deoxynojirimycin derivatives (miglitol, emiglitate)
- Other glucosidase inhibitors
- References
- Clinical evaluation of glucosidase inhibitors.
- Conclusions
- References
- Oral antidiabetic drugs in research and development
- Introduction
- Stimulation and modulation of insulin secretion
- Suppression of hepatic glucose production
- Enhancement of insulin action
- Mimicking insulin action
- Prevention of deleterious effects caused by glucose
- References
- New approaches for the treatment of diabetes mellitus
- Prevention
- Obesity
- Insulin sensitizers
- Alternative insulin delivery
- Gene therapy
- References
- Subject index.