Peroxisomes : biology and importance in toxicology and medicine /

Bibliographic Details
Other Authors: Gibson, G. Gordon, Lake, Brian, 1948-
Format: Book
Language:English
Published: London ; Washington, DC : Taylor & Francis, 1993.
Subjects:
Table of Contents:
  • Peroxisome biogenesis
  • Metabolic role of mammalian peroxisomes
  • Peroxisomal disorders
  • Molecular mechanism of peroxisome proliferator action
  • Peroxisome proliferators as cytochrome P450 inducers
  • Peroxisome proliferation: lipid metabolism and receptors
  • Molecular mechanisms involved in induction of peroxisomal -oxidation enzymes by hypolipidaemic agents
  • Molecular basis of gene regulation by peroxisome proliferators
  • Molecular evolution of the urate oxidase encoding gene and its functional significance
  • Possible role of CoASH esters on xenobiotic-induced peroxisomal proliferation and non-genotoxic carcinogenesis
  • Modulation of peroxisomal biogenesis and lipid metabolising enzymes by dietary factors.
  • (cont) Proliferation of peroxisomes and mitochondria and modulation of lipid metabolizing enzymes by hypolipidaemic, non-oxidizable fatty acids (3-thia fatty acids)
  • Cultured hepatocytes: a useful in vitro system to investigate effects induced by peroxisome proliferators and their species specificity
  • Structure-activity relationships for chemically induced peroxisome proliferation in mammalian liver
  • Tetrazole substituted acetophenone peroxisome proliferators: structure-activity relationships and effects on hepatic lipid metabolism
  • Structural requirements for peroxisome proliferation by phenoxyacetic and fatty acid analogues in primary cultures of rat hepatocytes
  • Ultrastructural and biochemical aspects of peroxisome proliferation and biogenesis in different mammalian species
  • Toxicological studies in primates with three fibrates.
  • Structure-, enantiomer- and species-specific effects of fibrate analogues on peroxisome proliferation and increased activity of mitochondrial α-glycerophosphate dehydrogenase
  • Metabolism of di-(2-ethylhexyl)phthalate (DEHP) and di-(2-ethylhexyl)adipate (DEHA) and their relationship to peroxisome proliferation in different species
  • Extrahepatic peroxisome proliferation and the extrahepatic effects of peroxisome proliferators
  • Biological aspects of peroxisome proliferator-induced liver tumours in the rat
  • Genotoxicity studies of peroxisome proliferators
  • Production of 8-hydroxydeoxyguanosine in rodent liver by the administration of peroxisome proliferators
  • Role of oxidative stress and enhanced cell replication in the hepatocarcinogenicity of peroxisome proliferators
  • Hyperplastic responses to peroxisome proliferators.
  • (cont) Hepatic changes associated with peroxisome proliferation
  • Peroxisome proliferators as initiators and promoters of rodent hepatocarcinogensis
  • Are peroxisome proliferators tumour promoters in rat liver?
  • Risk assessment of chemicals inducing peroxisome proliferation.