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Capacitative calcium entry /

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Bibliographic Details
Main Author: Putney, James W.
Format: Book
Language:English
Published: New York : Austin, [Tex.] : Chapman & Hall ; R.G. Landes, [1997]
Series:Molecular biology intelligence unit.
Subjects:
Calcium > metabolism.
Calcium Channels > physiology.
Electric Conductivity.
Cell Membrane > physiology.
Signal Transduction > physiology.
Table of Contents:
  • Pt. 1. General aspects of calcium signaling
  • The Concept of calcium as a cellular signal
  • Measurement of cellular calcium levels and movements
  • Calcium stores, calcium pools
  • The Phosphoinositide story
  • (145)IP3 receptors and intracellular Ca2 release
  • Metabolism of inositol phosphates
  • Calciosomes
  • Intracellular calcium oscillations
  • Excitable vs. nonexcitable cells
  • Concluding remarks
  • Pt. 2. Capacitative calcuim entry
  • Biphasic calcium signaling
  • The capacitative model is proposed.
  • Proofs of the capacitative model: calcium overshoot, thapsigargin and Mn2 quench
  • The Pathway for calcium entry
  • Pt. 3. The Signal for capacitative calcium entry
  • Conformational coupling
  • Evidence against conformational coupling
  • Evidence for a diffusible messenger for capacitative calcium entry
  • Calcium as a signal for calcium entry
  • Calcium influx factor (CIF)
  • Metabolites of cytochrome P-450
  • Cyclic gmp
  • (1,3,4,5,)IP4
  • Tyrosine kinase
  • G-protein
  • Conclusions.
  • Pt. 4. Electrophysiology and regulation of capacitative calcium entry
  • Properties of I
  • Single channels
  • Regulation of capacitative Ca2 entry channels by feedback inhibition
  • Regulation of capacitative Ca2 entry channels by protein phosphorylation
  • Conclusions
  • Pt. 5. The Molecular nature of capacitative calcuim entry channels
  • Drosophila trp and trpl
  • Functional studies of expressed trp and trpl
  • Mammalian homologs of trp
  • Expression of mammalian trps
  • A plasma membrane (1,4,5) IP3 receptor.
  • Conclusions
  • Pt. 5. Physiological, pharmacological and pathological aspects of capacitative calcium entry
  • Physiological functions of capacitative calcium entry-short term responses
  • Physiological functions of capacitative calcium entry-long term responses
  • Pharmacology of capacitative calcium entry
  • Clinical uses of inhibitors of capacitative calcium entry
  • Pathology and toxicology of capacitative calcium entry
  • conclusion.