Refinement and reduction in animal testing : proceedings of a conference held in Philadelphia, Pennsylvania, September 17-18, 1992 /

Bibliographic Details
Corporate Author: Scientists Center for Animal Welfare
Other Authors: Niemi, Steven M., Willson, John E.
Format: Book
Language:English
Published: Bethesda, Md. (4805 St. Elmo Ave., Bethesda 20814) : Scientists Center for Animal Welfare, 1993.
Subjects:
Table of Contents:
  • Animal models and efficacy testing
  • Refinement in the care of dogs with gastric fistulas
  • Non-human primate models for HIV infections: surrogate markers as endpoints
  • Frog embryo teratogenesis assay-xenopus (FETAX): A non-mammalian method for developmental toxicity assessment
  • ADME/pharmacokenetics
  • Utility of ADME/PK in refining animal toxicology protocols
  • An evaluation of devices for continuous administration
  • Minimizing stress during physiological monitoring
  • Husbandry
  • Group housing dogs on GLP toxicology studies
  • Toxicology
  • The low volume eye test as a refinement of the Draize eye-irritation test
  • Refinements and reduction in animal use in immunotoxicological investigation
  • The use of the mouse local lymph node assay in contact sensitization risk assessment
  • Refinement and reduction in neurotoxicity testing
  • Acute and general toxicology
  • EPA/OPPTS activities.
  • Updating eye irritation test methods: Results of an IRAG workshop
  • International conference on harmonization: An update on toxicology guidelines.
  • International conference on harmonization guidelines: An update on reproductive toxicology/teratology
  • Concluding remarks.