Signal transduction mechanisms in cancer /
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| Format: | Book |
| Language: | English |
| Published: |
Austin :
R.G. Landes,
1995.
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| Series: | Molecular biology intelligence unit.
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| Subjects: |
Table of Contents:
- Mechanisms underlying growth autonomy
- Autocrine cycles
- Signaling by constitutively active or overexpressed growth factor receptors
- Post-receptor signaling in cancer
- Growth factor receptor subtypes
- Signaling through serpentine R7G receptors
- Signaling through receptors with intrinsic protein tyrosine kinase activity
- Signaling by hematopoietic cytokine receptors
- Signal transduction by lymphocyte antigen receptors
- Altered post-receptor signaling by receptor tyrosine kinases, cytokine and antigen receptors in tumors
- Signals leading to growth inhibition
- Uncontrolled cell proliferation as a result of deleted or mutated tumor suppressor genes
- Cell cycle and cancer.
- Programmed cell death and malignant transformation
- Signals involved in tumor promotion and progression
- Tumor promotion
- Tumor progression
- Angiogenesis
- Invasion and metastasis
- Cellular signaling as a target in tumor chemotherapy
- Rationale, selectivity, cytotoxic or cytostatic effects
- Growth factor antagonists and growth factor receptor blockers
- Bombesin/GRP antagonists
- Suramin and related polyanionic receptor blockers.
- Somatostatin analogues
- Receptors encoded by the erbB or erbB-2 proto-oncogenes as targets
- Receptor-tyrosine kinases as targets
- Inhibitors acting at the post-receptor level
- SH2-, SH3-, and PH-domains as targets
- Ras as a target
- Phospholipases as targets
- Ca(2+)-channels as targets
- Phosphatidylinositol-3-kinases (PI3K) as a target
- Protein kinase C as a target
- cAMP-dependent protein kinases and cAMP-specific phosphodiesterases as targets
- c-myc as a target
- Tumor angiogenesis as a target
- Induction of programmed cell death.