Biologic therapy of cancer /

Bibliographic Details
Other Authors: DeVita, Vincent T., Jr., 1935-, Hellman, Samuel, Rosenberg, Steven A.
Format: Book
Language:English
Published: Philadelphia : Lippincott, [1995]
Edition:Second edition.
Subjects:
Table of Contents:
  • Principles of biologic therapy of cancer
  • Biology of cellular immune responses
  • Biology of antibody-mediated responses
  • Biology of tumor antigens
  • Gene coding for tumor antigens recognized by T lymphocytes
  • Tumor antigens recognized by immune cells
  • Tumor antigens recognized by monoclonal antibodies
  • Biology of cytokines: the interleukins
  • Principles of cell killing by biologic agents
  • Immunocompetence and cancer
  • Biologic therapy of cancer
  • Colony-stimulating factors: basic principles and preclinical studies.
  • Colony-stimulating factors: clinical applications
  • Granulocyte-stimulating factors
  • Platelet-stimulating factors
  • Erythrocyte-stimulating factors
  • Macrophage-colony stimulating factors
  • Biologic therapy with interleukin-2: preclinical studies
  • Biologic therapy with interleukin-2: clinical applications
  • Principles of administration and management of side effects
  • Melanoma
  • Renal cell cancer
  • Other cancers
  • Role of IL-4, IL-6, and IL-12 in cancer therapy
  • Biologic therapy with TNF: preclinical studies.
  • Biologic therapy with TNF: systemic administration and isolation-perfusion
  • Biologic therapy with interferon-α and †: preclinical studies
  • Biologic therapy with interferon α and †: clinical applications
  • Hairy cell leukemia, chronic myelogenous leukemia, and myeloproliferative disorders
  • Renal cell cancer
  • Melanoma
  • Kaposi's sarcoma
  • Multiple myeloma
  • Clinical applications of interferon in other tumors
  • Biologic therapy with interferon-γ
  • Combination cytokine therapy
  • Cell transfer therapy: preclinical studies.
  • Cell transfer therapy: clinical applications
  • Monoclonal antibodies in cancer therapy
  • Basic principles
  • Immunotoxins and recombinant toxins
  • Radioisotope conjugates
  • Clinical applications of monoclonal antibodies in cancer
  • B-cell lymphomas
  • T-cell leukemia/lymphoma
  • Melanoma
  • Adenocarcinomas
  • Purging of bone marrow
  • Antibodies to growth factors and receptors
  • Cancer vaccines: preclinical studies
  • Cancer vaccines: clinical applications
  • Immune adjuvants
  • Whole cell vaccines
  • Viral oncolysates.
  • Partially purified tumor antigen vaccines
  • Immunization with synthetic or highly purifed tumor antigens
  • Local therapy with biologic agents
  • Intralesional therapy
  • Instillation therapy for bladder cancer
  • Gene therapy of cancer
  • Basic principles and safety considerations
  • Gene therapy using lymphocyte modifications
  • Gene therapy using stem cell modification
  • Gene therapy using "Suicide" genes
  • Gene therapy by direct gene transfer
  • Antisense oligodeoxynucleotides
  • Gene modification of tumors.
  • Other approaches to biologic therapy
  • Chemically defined immunomodulators and interferon inducers
  • Levamisole
  • Differentiation agents
  • Tamoxifen
  • Systemic activation of macrophages by liposomes containing immunomodulators
  • Antimetastatic therapy
  • Interaction of biologic agents with chemotherapy
  • Regulatory issues related to biologic agents
  • Development of biological therapeutics for oncologic use.