Molecular mechanisms in striated muscle /
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| Format: | Book |
| Language: | English |
| Published: |
Cambridge ; New York :
Cambridge University Press,
1996.
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| Series: | Lezioni lincee.
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| Subjects: |
Table of Contents:
- Pt. 1. General aspects of motile systems
- Actin-based motor protein systems
- Tubulin-based motor protein systems
- General features of eucaryotic motor proteins
- Motility in procaryotes
- Pt. 2. Mechanochemistry of contraction
- Actin
- Myosin
- Organisation of actin and myosin in the myofibril
- Interaction of actin with myosin and ATP hydrolysis
- Cross-bridge structure and function
- Model motile systems
- Structure of the myosin head
- Structural aspects of the actin-myosin interaction.
- Pt. 3. Calcium and the regulation of contraction
- Sarcoplasmic reticulum
- Calcium-binding proteins of muscle
- Kinetics of calcium release
- Pt. 4. I filament regulation
- Regulatory proteins of the myofibril
- Possible mechanisms of troponin-mediated regulation
- Pt. 5. Regulation of muscle function by phosphorylation
- Tropomyosin
- Troponin system
- Myosin
- Phospholamban
- Common features of reversible phosphorylation systems in functioning muscle
- Pt. 6. Dystrophin and the muscular dystrophies.
- Duchenne muscular dystrophy
- Identification of the genetic lesion in Duchenne and Becker muscular dystrophies
- The dystrophin gene and its product
- Utrophin
- Functions of dystrophin
- Gene changes in Xp21 myopathies
- Animal models
- Treatment.