Human vaccines and vaccination /
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| Other Authors: | |
| Format: | Book |
| Language: | English |
| Published: |
Oxford :
BIOS Scientific Publishers,
1995.
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| Series: | Medical perspectives series.
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| Subjects: |
Table of Contents:
- Communicable diseases: The problem and some solutions
- An overview of communicable diseases
- A short history of vaccine development: Jenner's legacy
- Vaccination practice in developed countries
- Vaccination practice in developing countries
- The need for new and improved vaccines
- References
- Etiological agents of communicable diseases requiring new or improved human vaccines
- Viruses
- Bacteria
- Chlamydia
- Parasitic protozoa
- Parasitic helminths
- Mechanisms of pathogenesis
- Anatomical sites used by pathogens to gain entry into the human body
- Localized infections
- Systemic infections
- Organs or tissues targeted by pathogens following their systemic spread
- Oncogenic virus infections
- Opportunistic virus infections
- Transmission of infectious diseases
- Innate and required immune responses.
- Innate responses to infection
- Acquired immune responses to infection
- Humoral immunity
- Cell-mediated immunity
- T lymphocytes
- Antigens
- Cytokines
- References
- Immune responses to infectious and parasitic diseases
- Innate immunity
- Acquired immunity
- Antigenic diversity.
- Antigenic complexity
- Latent infections
- Modulation of immune responses
- Immune evasion
- Anamnestic immune responses
- Protective immune responses
- References
- Identification and analysis of vaccine antigens
- The role of molecular biology in vaccine development
- Identification and cloning of antigens
- Characterization of vaccine antigens: B-cell epitopes
- Characterization of vaccine antigens: T-cell epitopes
- References
- Developing new vaccines: Inactivated and subunit approaches
- Inactivated vaccines
- Expression systems and subunit vaccines
- Peptide vaccines
- Anti-idiotypes
- Genetic immunization
- Issues of presentation
- References
- New and improved live attenuated vaccines
- Improving attenuation: Pseudorabies- a veterinary vaccine pardigm
- Improving attenuation: V. cholerae
- Improving stability: Poliovirus
- Recombinant live vectors
- Vaccinia virus recombinants.
- Cross-species vaccination: 'Live-dead' vaccines
- BCG
- Attenuated salmonella strains as live recombinant bacterial vaccines
- Poliovirus chimeras
- Other virus vectors
- Recombinant e. coli strains.
- Improving immunogenicity: Examples from vaccinia virus
- References
- EBV vaccine development: A laboratory-based case study
- Natural history and clinical significance of EBV
- Rationale for EBV program
- Vaccine design for EBV
- Identification and characterization of EBV antigens
- Vaccines based on gp340
- References
- HBV vaccines- from the laboratory to license: A case study
- Epidemiology and disease in HBV infection
- HBV structure
- HBV vaccines
- Problems
- Further development
- Practical considerations: From laboratory to arm
- References
- Discussion
- Why vaccinate?- prevention is better than cure
- Herd immunity and its control of infectious and parasitic diseases
- Elimination of an infectious disease: Smallpox eradication
- The argument for expanded programs of immunization
- The need for new or improved vaccines
- Sterile immunity: Is it possible?
- New and re-emerging infectious diseases
- References.