Table of Contents:
  • Introduction / Rao S. Rapaka, Heinz Sorer
  • Targeting drugs to the brain by sequential metabolism / Nicholas Bodor
  • Action of opioid drugs on the brain-reward system / Conan Kornetsky
  • Drugs that modify opioid tolerance, physical dependence, and abstinence symptoms: preclinical and clinical studies / Hemendra N. Bhargava
  • Future directions in the pharmacological management of hyperalgesic and allodynic pain states: the NMDA receptor / Tony L. Yaksh, Sandra R. Chaplan, Annika B. Malmberg
  • Dual inhibitors of enkephalin-degrading enzymes (neutral endopeptidase 24.11 and aminopeptidase N) as potential new medications in the management of pain and opioid addiction / Bernard P. Roques, Florence Noble
  • Enhanced N-methyl-D-aspartate (NMDA)-induced activity following morphine: sensitivity to sigma and PCP ligands / Alice A. Larson, Rustam Yu. Yukhananov, Julie S. Kreeger
  • Dynorphin A: a rectifying peptide / Nancy M. Lee
  • Inhibitors of nitric oxide synthase and the opioid withdrawal syndrome / Edythe D. London, Alane S. Kimes, D. Bruce Vaupel
  • Nitric oxide and opioid tolerance / Gavril W. Pasternak
  • Methoclocinnamox: a partial agonist with pharmacotherapeutic potential for heroin use / James H. Woods ... [et al.]
  • ACEA-1011, a novel NMDA receptor/glycine site antagonist, produces antinociception but not tolerance in the formalin test in mice / Kabirullah Lutfy, John F.W. Keana, Eckard Weber
  • Etorphine elicits unique inhibitory-agonist and excitatory-antagonist actions at opioid receptors on sensory neurons: new rationale for improved clinical analgesia and treatment of opiate addiction / Stanley M. Crain, Ke-Fei Shen
  • The association of neuropathic pain, morphine tolerance and dependence, and the translocation of protein kinase C / David J. Mayer, Jianren Mao, Donald D. Price.