Exocyclic DNA adducts in mutagenesis and carcinogenesis /
| Corporate Authors: | , |
|---|---|
| Other Authors: | , |
| Format: | Book |
| Language: | English |
| Published: |
Lyon :
International Agency for Research on Cancer,
1999.
|
| Series: | IARC scientific publications ;
no. 150. |
| Subjects: |
Table of Contents:
- Keynote address: Exocyclic adducts as new risk markers for DNA damage in man / H. Bartsch
- Ch. 1. Occurrence and methods of detection
- Chemistry and biology of DNA damage by malondialdehyde / L.J. Marnett
- Formation and repair of DNA adducts in vinyl chloride- and vinyl fluoride-induced carcinogenesis / J.A. Swenberg ... [et al.]
- Role of 1,N²-propanodeoxyguanosine adducts as endogenous DNA lesions in rodents and humans / F.-L. Chung ... [et al.]
- Lipid peroxidation-induced etheno-DNA adducts in humans / J. Nair
- Detection of 1, N⁶-etheno-2́-deoxyadenosine and 3,N⁴-etheno-2́-deoxycytidine occurring endogenously in DNA / W.P. Watson ... [et al.]
- Ch. 2. Chemistry
- Possible mechanisms of carcinogenesis after exposure to benzene / B.T. Golding, W.P. Watson
- Synthesis of para-benzoquinone and 1,3-bis(2-chloroethyl)nitrosourea adducts and their incorporation into oligonucleotides / A. Chenna, H. Maruenda, B. Singer
- Purine DNA adducts of 4,5-dioxovaleric acid and 2,4-decadienal / J. Cadet ... [et al.]
- Adducts of chlorohydroxyfuranones and of aldehyde conjugates / L. Kronberg ... [et al.]
- Cyclic adducts and intermediates induced by simple epoxides / J.J. Solomon
- Ch. 3. Formation from exogenous and endogenous sources
- Formation of etheno adducts and their effects on DNA polymerases / F.P. Guengerich ... [et al.]
- Reactions of α-acetoxy-N-nitrosopyrrolidine and crotonaldehyde with DNA / S.S. Hecht, P. Upadhyaya, M. Wang
- Glyoxal-guanine DNA adducts: detection, stability and formation in vivo from nitrosamines / R.N. Loeppky ... [et al.]
- Ch. 4. Physiochemical approaches to structural elucidation
- Effects of 3,N⁴-etheno-deoxycytidine on duplex stability and energetics / G.E. Plum, C.A. Gelfand, K.J. Breslauer
- Solution structures of DNA duplexes containing the exocyclic lesion 3,N⁴-etheno-2́-deoxycytidine / D. Cullinan, M. Eisenberg, C. de los Santos
- Thermal destabilization of DNA oligonucleotide duplexes by exocyclic adducts on adenine or cytosine depends on both the base and the size of the adduct / J. Sági, B. Singer
- Ch. 5. Cyclic adducts as biomarkers
- A sensitive immunoslot-blot assay for detection of malondialdehyde-deoxyguanosine in human DNA / C. Leuratti ... [et al.]
- ³²P-postlabelling with high-performance liquid chromatography for analysis of abundant DNA adducts in human tissues / K. Yang ... [et al.]
- Cancer risk assessment for crotonaldehyde and 2-hexenal: an approach / E. Eder, D. Schuler, Budiawan
- Ch. 6. DNA repair and effects on replication
- Mammalian enzymatic repair of etheno and para-benzoquinone exocyclic adducts derived from the carcinogens vinyl chloride and benzene / B. Singer, B. Hang
- Enzymology of the repair of etheno adducts in mammalian cells and in Eschericia coli / M. Saparbaev, J. Laval
- Cellular response to exocyclic DNA adducts / M. Moriya ... [et al.]
- Role of base excision repair in protecting cells from the toxicity of chloroethylnitrosoureas / D.B. Ludlum, Q. Li, Z. Matijasevic
- Localization of chloroacetaldehyde-induced DNA damage in human p53 gene by DNA polymerase fingerprint analysis / B. Tudek, P. Kowalczyk, J.M. Cieúla
- Ch. 7. Mutagenesis and carcinogenesis
- Cancer-prone oxyradical overload disease / S. Ambs ... [et al.]
- Role of etheno DNA adducts in carcinogenesis induced by vinyl chloride in rats / A. Barbin
- Vinyl chloride-specific mutations in humans and animals / M.J. Marion, S. Boivin-Angele
- Solution conformation and mutagenic specificity of 1,N⁶-ethenoadenine / A.K. Basu, J.M. McNulty, W.G. McGregor
- Genetic effects of exocyclic DNA adducts in vivo: heritable genetic damage in comparison with loss of heterozygosity in somatic cells / M.J.M. Nivard, E.W. Vogel
- Appendix: Distortion of the double helix by para-benzoquinone adducts / J. Sági, B. Singer.