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Principles of biochemical toxicology /

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Bibliographic Details
Main Author: Timbrell, John
Format: Book
Language:English
Published: London ; Philadelphia : Taylor & Francis, 2000.
Edition:Third edition.
Subjects:
Poisoning > metabolism.
Poisons > metabolism.
Poisoning > physiopathology.
Xenobiotics > adverse effects.
Table of Contents:
  • Introduction
  • Background
  • Scope
  • Biochemical aspects of toxicology
  • Dose-response relationships
  • Criteria of toxicity
  • Dose-response
  • Measurement of dose-response relationships
  • Hazard and risk assessment
  • Chronic toxicity
  • Factors affecting toxic responses: disposition
  • Absorption
  • Sites of absorption
  • Distribution
  • Excretion
  • Factors affecting toxic responses: metabolism
  • Types of metabolic change
  • Phase 1 reactions
  • Phase 2 reactions
  • Control of metabolism
  • Toxication versus detoxication
  • Factors affecting metabolism and disposition
  • Chemical factors
  • Biological factors
  • Toxic responses to foreign compounds
  • Direct toxic action: tissue lesions
  • Pharmacological, physiological and biochemical effects
  • Teratogenesis
  • Immunotoxicity
  • Genetic toxicity
  • Chemical carcinogenesis
  • Biochemical mechanisms of toxicity: specific examples
  • Chemical carcinogenesis
  • Tissue lesions: liver necrosis
  • Tissue lesions: kidney damage
  • Tissue lesions: lung damage
  • Neurotoxicity
  • Exaggerated and unwanted pharmacological effects
  • Physiological effects
  • Biochemical effects: lethal synthesis and incorporation
  • Biochemical effects: interaction with specific protein receptors
  • Teratogenesis
  • Immunotoxicity
  • Multi-organ toxicity
  • Multi-organ toxicity: metals.