DNA alterations in cancer : genetic and epigenetic changes /
| Other Authors: | |
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| Format: | Book |
| Language: | English |
| Published: |
Natick, MA :
Eaton Pub.,
[2000]
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| Subjects: |
Table of Contents:
- Sect. 1. Introduction
- Introduction to cancer genes and growth control / Nesrin Özören, Wafik S. El-Deiry
- Sect. 2. Tumor suppressor genes and cancer modifier loci
- Rb and other pocket proteins, chromatin remodeling, and cancer / Slimane Ait-Si-Ali ... [et al.]
- The hedgehog/patched signaling pathway: the role of tumor suppressor genes in development / Michael Dean
- Structure-function relationship of the INK4 family of tumor suppressors / Junan Li ... [et al.]
- The role of genetic modifiers, both mutations and polymorphisms, and environmental factors in cancer susceptibility / Bharati Bapat, Susmita Esufali
- Sect. 3. Activation of the oncogenic function of proto-oncogenes and other cancer promoting genes by mutation or rearrangement
- Multiple roles for deregulated MYC expression in oncogenesis / Amato J. Giaccia, Nicholas C. Denko
- Misregulation of a signal transduction pathway: the role of Rel/NF-B transcription factors in oncogenesis / Thomas D. Gilmore, Jean-Charles Epinat, Margaret Barkett
- Fusion oncoproteins resulting from chromosomal translocations and leukemogenesis / Randy Fenrick, Scott W. Hiebert
- Dissecting the genetics of the RET proto-oncogene: paradigm for molecular medicine / Lois M. Mulligan, Charis Eng
- Sect. 4. DNA repair and cancer
- DNA repair pathways and changes in cancer / Vilhelm A. Bohr
- Mutagenesis and tumor development in DNA mismatch repair-deficient mice / Susan E. Andrew, Peter M. Glazer, Frank R. Jirik
- LOH and mitotic recombination / Maria Jasin
- Sect. 5. Inherited mutations contributing to oncogenesis
- Cancer susceptibility genes: germline mutations and polymorphisms conferring high risks of neoplasia / William P. Bennett
- ATM: at the crossroads of DNA damage response, cell-cycle control, genome stability, and cancer / Galit Rotman, Yosef Shiloh
- Molecular basis of predisposition to colon cancer / Nickolas Papadopoulos
- Inherited susceptibility to breast cancer in women: high-penetrance and low-penetrance genes / Timothy R. Rebbeck
- Sect. 6. DNA methylation, imprinting, and cancer
- DNA hypomethylation and cancer / Melanie Ehrlich
- Epigenetics and loss of gene function in cancer / Stephen B. Baylin, James G. Herman
- Hypermethylator phenotypes in aging and cancer / Jean-Pierre Issa
- 5-methylcytosine and human cancer mutations: lessons from p53 / Mikhail Denissenko, Gerd P. Pfeifer
- Genomic imprinting and human neoplasia / Benjamin Tycko
- DNA methylation and methyltransferases / En Li, Rudolf Jaenisch
- Sect. 7. The contribution of karyotypic instability to cancer formation and tumor progression
- Chromosome and karyotype instability to cancer formation and tumor progression
- Chromosome and karyotype instability in human cancers and cancer-predisposing syndromes / Bernard Dutrillaux
- Clonal evolution of neoplastic cell populations: lessons from solid tumor cytogenetics / Sverre Heim, Manuel R. Teixeira
- The role of fragile sites in gene amplification and genome remodeling / Michelle Debatisse, Franck Toledo, Arnaud Coquelle
- p53 and the development of genomic instability: possible role of topoisomerase I interaction / Amador Albor, Molly Kulesz-Martin
- Sect. 8. New strategies for cancer therapies
- Telomerase as a potential target for anticancer therapies / John K. Cowell
- New p53-based strategies for cancer therapy / Ute M. Moll
- Therapeutic resistance of erbB-2-overexpressing cancers and strategies to overcome this resistance / Dihua Yu, Mien-Chie Hung
- The DNA repair protein O⁶-alkylguanine-DNA alkyltransferase as a target for cancer chemotherapy / Anthony E. Pegg, Meng Xu-Welliver, Natalia A. Loktionova
- Acquired drug resistance driven by tumor cell genetic instability: circumvention by direct-acting anti-angiogenic vascular targeting agents / Robert S. Kerbel.