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Structure and mechanism in protein science : a guide to enzyme catalysis and protein folding /

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Bibliographic Details
Main Author: Fersht, Alan, 1943-
Format: Book
Language:English
Published: New York : W.H. Freeman and Company, [1999]
Subjects:
Protein Folding.
Protein Structure.
Enzymes.
Table of Contents:
  • The three-dimensional structure of proteins
  • Chemical catalysis
  • The basic equations of enzyme kinetics
  • Measurement and magnitude of individual rate constants
  • The pH dependence of enzyme catalysis
  • Practical methods of kinetics and equilibria
  • Detection of intermediates in enzymatic reactions
  • Stereochemistry of enzymatic reactions
  • Active-site-directed and enzyme-activated irreversible inhibitors : "affinity labels" and "suicide inhibitors"
  • Conformational change, allosteric regulation, motors, and work
  • Forces between molecules, and binding energies
  • Enzyme-substrate complementarity and the use of binding energy in catalysis
  • Specificity and editing mechanisms
  • Recombinant DNA technology
  • Protein engineering
  • Case studies of enzyme structure and mechanism
  • Protein stability
  • Kinetics of protein folding
  • Folding pathways and energy landscapes