Biomedical chemistry : applying chemical principles to the understanding and treatment of disease /
| Other Authors: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York :
Wiley-Interscience,
[2000]
|
| Subjects: |
Table of Contents:
- Pt. 1. Drug discovery and development leads from fundamentals of enzyme transformations and mechanisms
- Sleeping sickness: irreversible inhibitors of S-adenosylmethionine decarboxylase as antitrypanosomal agents / P.M. Woster
- Mechanism-based S-adenosyl-L-homocysteine hydrolase inhibitors in the search for broad-spectrum antiviral agents / D. Yin ... [et al.]
- Alcoholism: aldehyde dehydrogenase inhibitors as alcohol deterrent agents / H.T. Nagasawa, F.N. Shirota, E.G. DeMaster
- AIDS: adenosine deaminase-activated prodrugs for the treatment of human immunodeficiency virus in the central nervous system / J.S. Driscoll
- Anti-HIV phosphotriester pronucleotides: basis for the rational design of biolabile phosphate protecting groups
- C. Perigaud, G. Gosselin, J.-L. Imbach
- Pt. 2. Exploration of fundamental chemical principles in drug design and discovery
- AIDS: potential inhibitors of human immunodeficiency virus replication / G.L. Kenyon
- From chemical warfare agent to anticancer drug: the chemistry of phosphoramide mustard / S.M. Ludeman
- Phosphoryltyrosyl mimetics as signaling modulators and potential antitumor agents / T.R. Burke, Jr., Y. Gao, Z.-J. Yao
- Targeting tumors using magnetic drug delivery / S.K. Pulfer, J.M. Gallo
- Cancer: superacid generation of new antitumor agents / J.-C. Jacquesy, J. Fahy
- Fluorine substitution as a modulator of biological processes / K.L. Kirk
- Pt. 3. Understanding the chemical basis of drug action and disease
- Thiouracil and related thioureylene compounds as melanoma-seekers: paradigms for a chemical approach to the design of targeting anticancer agents / M. d'Ischia, G. Prota
- Carbon-centered radicals and rational design of new antimalarial peroxide drugs / G.H. Posner, J.N. Cumming, M. Krasavin
- The chemistry of Parkinson's disease / G. Dryhurst ... [et al.]
- Pt. 4. Novel chemistries in the vanguard of biotechnology and drug discovery
- New generation of DNA chips based on real-time biomimetic recognition / F. Garnier
- Peptide nucleic acids (PNA): towards gene therapeutic drugs / P.E. Nielsen
- Ribozyme mimics: the evolution of gene-specific chemotherapy / T.A. Osiek, W.C. Putnam, J.K. Bashkin.