Protein structure prediction : a practical approach /

Bibliographic Details
Other Authors: Sternberg, Michael J. E.
Format: Book
Language:English
Published: Oxford ; New York : IRL Press at Oxford University Press, [1996]
Series:Practical approach series ; 170.
Subjects:

MARC

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245 0 0 |a Protein structure prediction :  |b a practical approach /  |c edited by Michael J.E. Sternberg. 
264 1 |a Oxford ;  |a New York :  |b IRL Press at Oxford University Press,  |c [1996] 
264 4 |c ©1996 
300 |a xviii, 298 pages :  |b illustrations (some color) ;  |c 24 cm. 
336 |a text  |2 rdacontent  |b txt 
337 |a unmediated  |2 rdamedia 
338 |a volume  |2 rdacarrier  |b nc 
490 1 |a The Practical approach series ;  |v 170 
504 |a Includes bibliographical references and index. 
505 0 |a 1. Protein structure prediction - principles and approaches -- Introduction -- Dominant effects in protein folding -- Analyses of protein structure -- Sequence analysis -- Secondary structure prediction -- Tertiary structure prediction -- Simulations with protein structures -- Conclusion -- 2. Protein sequence alignment and database scanning -- Introduction -- Amino acid scoring schemes -- Comparison of two sequences -- Evaluation of alignment accuracy -- Multiple sequence alignment -- Database scanning -- Summary -- 3. Identification of protein sequence motifs -- Introduction -- Identification of protein sequence motifs -- Pattern extraction -- Summary -- 4. Prediction of secondary structure -- Introduction : the need for secondary structure prediction -- Methods of secondary structure prediction -- Evaluating prediction methods -- A practical example -- Recommendations -- Conclusions -- 5. Prediction of transmembrane protein topology -- Introduction -- Structural classes : helix bundles and β-barrels -- Membrane insertion : setting-up the topology -- Prediction of transmembrane helics and membrane topology -- Prediction of transmembrane β-strands -- 6. Comparative modelling of proteins -- Introduction -- Different approaches to comparative modelling -- Accuracy of models and evaluation of models -- Use of protein models and summary comments -- 7. Antibody combining sites : structure and prediction -- Introduction -- Antibody structure -- Variable region modelling -- Accuracy, limitations, and future developments -- Applications -- Future prospects -- 8. Protein folds and their recognition from sequence -- Introduction -- Fold libraries -- Evaluating structural models -- Rold recognition methods -- Case study -- The asilomar competition -- Software availability -- Conclusions and future directions -- 9. The combinatorial approach -- Introduction -- Secondary structure prediction with tertiary intent -- Tertiary structure from secondary structure -- Sorting between alternative models -- Conclusion -- 10. Modelling protein conformation by molecular mechanics and dynamics -- Introduction -- Methods -- Applications -- Summary -- 11. Docking ligands to proteins -- Introduction -- Docking programs -- Preparing your input -- Docking a small molecule to a protein -- Docking a protein ligand to a protein receptor -- Novel inhibitor discovery -- 12. The prediction challenge 
650 2 |a Protein Conformation. 
650 2 |a Amino Acid Sequence. 
650 2 |a Computer Simulation. 
700 1 |a Sternberg, Michael J. E. 
830 0 |a Practical approach series ;  |v 170. 
999 |a MARS 
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