The structure and function of Alzheimer's amyloid beta proteins /
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Austin :
R.G. Landes,
1994.
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| Series: | Medical intelligence unit.
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| Subjects: |
Table of Contents:
- Amyloid and Alzheimer's disease: the first eighty years
- Amyloid
- Amyloid purification
- Amyloid beta protein precursor structure
- Structural properties of amyloid beta protein and its precursor
- Protease inhibitor insert
- Tyrosine sulfation
- Glycosylation
- Phosphorylation
- Heparin binding
- Interaction between A† and A†PP
- Interaction between A†PP and transforming growth factor beta
- Amyloid beta protein
- Alternative protein conformations
- Conformation of A† in amyloid
- A† sequence
- Physical chemical properties of A†.
- Mechanism of amyloid formation
- Rodent A† is conformationally distinct from human A†
- Aluminum
- A† interacts with apolipoprotein E
- Metabolism of amyloid beta protein precursor
- Secretory and endocytotic pathways
- A†PP secretion
- Alternative secretory processing of A†PP
- Lysosomal metabolism of A†PP
- Constitutive release of A†
- Origin of A†
- Genetics
- Chromosome 21
- Chromosome 14
- Chromosome 19
- Cell survival and neurotoxic effects of amyloid beta protein
- A† has cell survival activity.
- Neurotoxicity of endogenously synthesized A†PP
- Neurotoxicity of exogenously applied A†
- Mechanisms of A† toxicity
- Necrosis versus apoptosis
- Anticoagulant and adhesive properties of the amyloid beta protein precursor
- A†PP is a potent protease inhibitor and anticoagulant
- A†PP in the extracellular matrix
- Normal localization of A†PP
- Cellular adhesion
- Growth- and neurite-promoting activities of the amyloid beta protein precursor
- A†PP is a mitogen
- Identification of the rems sequence.
- A†PP promotes neurite outgrowth
- Cell survival activity of A†PP
- Regulation of A†PP synthesis and expression.