Myoblast transfer : gene therapy for muscular dystrophy /
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Austin :
R.G. Landes,
1994.
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| Series: | Medical intelligence unit.
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| Subjects: |
Table of Contents:
- Development of normal and dystrophic mammalian skeletal muscles
- Embryogenesis
- Motor unit
- Dystrophic myogenesis
- Motor units in neuromuscular disorders
- Pathogenesis of muscular dystrophy
- Broad perspective
- Duchenne muscular dystrophy
- Murine dystrophy: general membrane defect
- Dystrophic nervous system supports normal muscle development
- Muscle transplantation and regeneration
- Normal regenerates
- Dystrophic regenerates
- Conceptual approaches
- Pharmaceutics
- Gene transfer
- Dystrophic genes
- Dystrophin
- Dystrophin up-regulation.
- Plasmid injection
- Transduced myoblast transfer
- Concerns about transgenics
- Dystrophin-associated glycoproteins (DAGs)
- Perspectives
- Myoblast transfer
- What is MTT
- How MTT works
- Origin of MTT
- Neural hypothesis of muscular dystrophy
- Animal models
- Cell therapy vs. gene therapy
- Development of MTT
- Myoblast transfer in dystrophic animals
- Myoblast transfer improves muscle genetics/biochemistry/structure/function and normalizes the behavior and life span of dystrophic mice
- Myoblast transfer in DMD subjects.
- Single muscle treatment
- Subjects and methods
- Results
- Lower body treatment
- Methods
- Results
- Discussion
- Whole body treatment
- Rationale
- Readministration and naive protocols
- Objective
- Study design
- Methods
- Preliminary results
- Future perspectives
- Treatment of hereditary degenerative diseases
- Why cell therapy
- Essence of cell therapy
- Ultimate gene transfer
- Controlled cell fusion
- Myotube development
- Myoblasts: the universal gene transfer vehicles
- Superior cell lines.
- Myoblast injection methods
- Exercise and physical therapy
- Myotube transfer
- Automated cell processors
- Cell banks
- Allophenic mice
- Transgenic mice
- Cell therapy is the medicine of the future.