Health risk assessment : dermal and inhalation exposure and absorption of toxicants /

Bibliographic Details
Other Authors: Wang, Rhoda G. M., 1947-, Knaak, James B., Maibach, Howard I.
Format: Book
Language:English
Published: Boca Raton : CRC Press, [1993]
Series:CRC series in dermatology.
Subjects:
Table of Contents:
  • Physiologically based pharmacokinetic modeling to predict tissue dose and cholinesterase inhibition in workers exposed to organophosphorus and carbamate pesticides
  • Application of pharmacokinetic mosels to predict target dose
  • Cytochrome P450-dependent metabolism of drugs and carcinogens in skin
  • Percutaneous absorption
  • In vitro skin metabolism
  • Animal models for percutaneous absorption
  • Comparative study of the kinetics and bioavailability of pure and soil-absorbed benzene, toluene, and m-xylene after dermal exposure
  • Prediction of human percutaneous absorption with physicochemical data
  • Dermal absorption of TCDD: effect of age.
  • (cont) Percutaneous absorption of chemicals from water during swimming and bathing
  • Percutaneous absorption of contaminants from soil
  • General overview on toxicological responses and routes of chemical exposure
  • Acute toxicity testing by the dermal route
  • Subchronic dermal exposure studies with industrial chemicals
  • Dose response of percutaneous absorption
  • Reproductive and developmental toxicity studies by cutaneous administration
  • Dermal carcinogenicity studies of petroleum-derived materials
  • Comparison of results from carcinogenicity tests of two halogenated compounds by oral, dermal, and inhalation routes
  • Objectives and goals of dermal carcinogenicity testing of petroleum liquids.
  • (cont) Chemical carcinogenesis in skin: causation, mechanism, and role of oncogenes
  • Incorporating biological information into the assessment of cancer risk to humans under various exposure conditions and issues related to high background tumor incidence rates
  • Phototoxicity of topical and systemic agents
  • Techniques for assessing the health risks of dermal contact with chemicals in the environment
  • Interspecies extrapolation of toxicological data
  • Human skin xenografts to athymic rodents as a system to study toxins delivered to or through the skin
  • Isolated perfused porcine skin flap
  • Perspectives on assessment of risk from dermal exposure to polycyclic aromatic hydrocarbons
  • Paradox of herbicide 2,4-D epidemiology
  • Review of epidemiologic studies with regard to routes of exposure to toxicants.