Interferon : principles and medical applications /
| Other Authors: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Galveston, TX :
University of Texas Medical Branch at Galveston, Dept. of Microbiology,
1992.
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| Edition: | First edition. |
| Subjects: |
Table of Contents:
- Transcription of mammalian genes encoding proteins: survey of the machinery and its control
- Interferon α/β, gne structure and regulation
- IFN γ, gene structure and regulation
- Interferon inducers
- Principles of protein structure and function applicable to most proteins: aspects of protein structure, function and evolution
- Human interferon alpha family: protein structure and function
- Human interferon β, protein structure and function
- Gamma interferon, protein structure and function
- Structure and function of the type I interferon receptor
- IFN γ receptor: protein structure and function
- Transmembrane secondary messengers for IFN α/β.
- (cont.) Cytoplasmic events in signal transduction leading to IFN α-induced gene expression
- Interfon γ signaling: current status and evidence for cross-talk with other interferons and cytokines
- Regulation of interferon-inducible genes
- MX protein: function and mechanism of action
- The 2-5 A system: 2-5 A synthetases, isospecies and functions
- The RNA-dependent P1/eIF-2α protein kinase
- Effects of interferons on mitochondria: regulation of mitochondrial gene expression
- Indoleamine 2,3-Dioxygenase
- Cell and animal effects of IFNs: natural occurrences and differentiation effects and mechanisms
- Antiviral effects of interferons: studies in animals and at the cellular level
- Mechanisms of interferons' antitumor actions.
- (cont.) Interferon as a mediator of host defense against bacteria
- Anti-protozoal effects and mechanisms
- Regulation of macrophage function by interferon γ
- IFN regulation of T cell function
- Interferons and the cytokine network: role in thymic and pituitary physiology, in endotoxin-induced shock and in cachexia
- The regulation of B cell function by interferon gamma
- Modulation of neutrophil functions by interferon gamma
- Introduction to clinical uses of interferons
- Biological basis for therapy and for side effects
- Pharmacokinetics of interferons and routes of administration
- Toxicity and side effects of interferons
- Interferon therapy of viral hepatitis
- Clinical use of interferons (IFNs) in respiratory and other viral diseases.
- (cont.) Kaposi's sarcoma and AIDS
- Clinical use of interferons: hairy cell, chronic myelogenous and other leukemias
- Multiple myeloma and lymphomas
- Cutaneous tumors: condyloma, basal cell carcinoma, squamous cell carcinoma and melanoma
- Clinical use of interferons: solid tumors
- Interferon gamma as infection prophylaxis in chronic granulomatous disease
- Clinical use of interferons in rare hematological diseases: type-II idiopathic cryoglobulinemia and essential thrombocythemia
- Clinical use of interferons in multiple sclerosis
- Interferon research in veterinary medicine.